Search Results - marian+young

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WNT1-Induced Secreted Protein-1 Knockout Mouse Model

WNT1-induced secreted protein-1 (WISP1) is expressed at high levels in osteoblasts and their precursors. WIPS1 plays an important role in various aspects of bone formation. Scientists at the NIH generated Wisp1-deficient (Wisp1-/-) mice. Deletion of Wisp1 resulted in a decrease in bone mineral density, total bone volume, bone thickness, and biomechanical...

Published: 7/25/2024 | Inventor(s): Azusa Maeda, Mitsuaki Ono, Marian Young

Keywords(s): DEFICIENT, Generation, Mice, OSTEOGENESIS, VAXXXX, VPXXXX, WISP1, WIXXXX, XCXXXX, XEXXXX, YCXXXX

Category(s): TherapeuticArea > Ophthalmology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, TherapeuticArea > Immunology, Application > Research Materials, TherapeuticArea > Geriatrics, Application > Diagnostics

Assay for the Detection of a Variety of Tumors in Biological Specimens

The inventors have developed methods and reagents for the detection of bone sialoprotein (BSP) in biological samples. The technology relates to the disruption of a serum complex that masks the majority of BSP from established detection systems. Furthermore, there is evidence that there may be a more acidic form of BSP secreted not by normal bone,...

Published: 7/25/2024 | Inventor(s): Larry Fisher, Neal Fedarko, Marian Young

Keywords(s): CAXXXX, CXXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics

A Mouse Model for Human Osteoarthritis

Osteoarthritis (OA) is the most common form of arthritis and affects more than 20 million Americans, costing billions of dollars in health care annually. Osteoarthritis is caused by the breakdown of joint cartilage, leading to a loss of the cartilage "cushion" between the bones of the joints. Risk factors associated with OA include age, obesity, traumatic...

Published: 7/25/2024 | Inventor(s): Ake Oldberg, Tianshun Xu, Marian Young, Laurent Ameye

Keywords(s): 47 XYY syndrome, BAXXXX, Double Y, IBXXXX, IDXXXX, IXXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, ResearchProducts > Animal Models