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Methods of Producing Effective T-cell Populations Using Akt Inhibitors

Abstract: Adoptive cell therapy (ACT) uses cancer reactive T-cells to effectively treat patients. However, several obstacles inhibit the successful use of ACT for cancer treatment. Current approaches for the expansion of T-cells may produce T-cells with a terminally differentiated phenotype that is associated with diminished anti-tumor activity and...

Published: 4/8/2024 | Inventor(s): Joseph Crompton, Nicholas Restifo

Keywords(s): act, AKT, CANCER, Immunotherapy. Adoptive Cell Therapy, Protein kinase B, Restifo, T-CELLS

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials