Search Results - rosanne+spolski

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Treatment of Viral Infection by Blocking Interleukin-21

Blocking interleukin (IL-21) may be an effective method to treat or prevent various viral infections. In the course of an immune response to a virus, IL-21, produced primarily by CD4+ T cells, can inhibit or stimulate (regulate), immune cell function (B cells, T cells, natural killer cells, dendritic cells). IL-21 regulation may be either protective...

Published: 4/8/2024 | Inventor(s): Rosanne Spolski, Warren Leonard

Keywords(s): Blocking, DBXXXX, DISCOVERING, DXXXXX, IL-21, INCREASES, Model, PNEUMONIA, SURVIVAL, That, viral

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease

IL-21 Critically Regulates Immunoglobulin Production

The invention includes a mouse in which the IL-21 receptor gene is disrupted by homologous recombination, the disruption being sufficient to prevent expression of the IL-21 receptor and thus to inhibit the action of IL-21. The invention also includes a mouse in which both the IL-21 receptor gene and the IL-4 gene are simultaneously disrupted in fashions...

Published: 7/25/2024 | Inventor(s): Warren Leonard, Katsutoshi Ozaki, Rosanne Spolski

Keywords(s): IBXXXX, IDXXXX, IXXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics