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Receptor-Mediated Uptake of an Extracellular Bcl-X_L Fusion Protein Inhibits Apoptosis

The present invention relates to the field of apoptosis, in particular, it relates to apoptosis-modifying fusion proteins with at least two domains, one of which targets the fusion proteins to a target cell, and another of which modifies an apoptotic response of the target cell. For example, fusing various cell-binding domains to Bcl-XL and Bad allows...

Published: 4/8/2024 | Inventor(s): Richard Youle

Keywords(s): Adult spinal muscular atrophy, Alzheimer disease 1, Alzheimer disease 3, Alzheimer disease 4, Alzheimer disease type 1, Alzheimer disease type 4, Alzheimer disease, familial, type 3, CB1XXX, CBXXXX, CXXXXX, Huntington disease, Huntington disease; Huntington's disease, Spinal muscular atrophy, Spinal Muscular Atrophy 1, Spinal muscular atrophy 4, Werdnig-Hoffmann disease

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Immunology