HOME
SEARCH
RSS FEED
SUBSCRIBE
Search Results - tdp1+inhibitors
1
Results
Sort By:
Published Date
Updated Date
Title
ID
Descending
Ascending
Phosphodiesterase as a target for cancer therapeutics
Abstract: Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a recently discovered enzyme that catalyzes the hydrolysis of 3'-phosphotyrosyl bonds. Such linkages form in vivo following the DNA processing activity of topoisomerase I (Top1). For this reason, Tdp1 has been implicated in the repair of irreversible Top1-DNA covalent complexes, which can be generated...
Published: 9/11/2024
|
Inventor(s):
Yves Pommier
,
Periyasamy Selvam
,
Christophe Marchand
,
Thomas Dexheimer
,
Kasthuraiah Maddali
Keywords(s):
Fluoroquinolone
,
PHOSPHODIESTERASE
,
Tdp1 inhibitors
Category(s):
Collaboration Sought > Licensing
,
Application > Therapeutics
,
Collaboration Sought > Collaboration
,
TherapeuticArea > Oncology
Home
|
Search
|
RSS
|
Subscribe
© 2024. All Rights Reserved. Powered by
Inteum