HOME
SEARCH
RSS FEED
SUBSCRIBE
Methods to Increase Stability of Recombinant Vaccinia-Vectored Vaccines and Increase Expression of a Foreign Gene Inserted in Such Vaccines
Case ID:
TAB-2068
Web Published:
12/6/2022
Description:
The technology offered for licensing is in the field of vaccinia-based recombinant vaccines. In particular the invention relates to methods of stabilizing the recombinant virus, thus resulting in efficient production of the vaccine and efficient expression of the inserted gene. Stabilization of the recombinant virus is achieved by the insertion of the exogenous gene into an intergenic region (IGR) of the viral genome (i.e. Modified Vaccinia Ankara, MVA), where the IGR is flanked by open reading frames of conserved poxvirus genes. Furthermore, the invention relates to plasmids vectors useful to insert the exogenous DNA into the genome of a vaccinia virus. Stability can be further enhanced by incorporating silent mutations that decrease the lengths of homopolynucleotide runs in the foreign gene.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
Direct Link:
https://nih.technologypublisher.com/tech/Methods_to_Increase_Stability_of_Rec ombinant_Vaccinia-Vectored_Vaccines_and_Increase_Expression_of_a_Foreign_Gen e_Inserted_in_Such_Vaccines
Category(s):
Licensing
Therapeutics
Bookmark this page
Download as PDF
For Information, Contact:
Benjamin Hurley
Office of Technology Transfer Center
NIH Technology Transfer
240-669-5092
benjamin.hurley@nih.gov
Inventors:
Patricia Earl
Linda Wyatt
Bernard Moss
Keywords:
ANKARA
Del
Expression
Fied
Foreign
GB1DXX
GB1XXX
GBXXXX
Gene
GENES
GXXXXX
INCREASE
Insertion
LIl
Modi
Modified
MVA
Patent Category - Biotechnology
PLASMID
SHUTTLE
SITE
STABILITY
vaccinia
Vector
virus
Home
|
Search
|
RSS
|
Subscribe
© 2024. All Rights Reserved. Powered by
Inteum