Mice with a Floxed Allele of the alpha Subunit of the Heterotrimeric G Protein Go or Gi2

Description:

Heterotrimeric G proteins couple signals between GPCRs (G protein coupled receptors) and effectors such as adenylyl cyclase, phospholipase C and ion channels. Among the G proteins are Go and Gi2. Go is highly expressed in the brain and some endocrine tissues while Gi2 is widely expressed throughout the body. The ß?-subunits of Go interact with ion channels, and the a subunit has been shown to inhibit adenylyl cyclase. However a physiological role of the Gi2a has not been determined in a tissue specific manner.

In this invention, mice with a floxed allele of the Go-a subunit and mice with a floxed allele of the Gi2a subunit were generated. These transgenic mice can be used to study the function of Go-a and the function of Gi2a in a tissue specific manner.