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Oxynitidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) for Treatin
g
Cancer
Summary: The National Cancer Institute (NCI) is actively seekin
g
potential licensees and/or co-development research collaboration partners interested in advancing oxynitidine derivatives as novel inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) for cancer treatment. These TOPI and TDP1 inhibitors, when administered...
Published: 9/18/2024
|
Inventor(s):
Yves Pommier
,
Lin-kun An
,
Keli A
g
ama
,
Ev
g
eny Kiselev
,
Azhar Ravji
Keywords(s):
Benzophenanthridine Derivatives
,
Benzophenanthridinone
,
Camptothecin
,
Dihydrobenzophenanthridine
,
IRINOTECAN
,
Oxynitidine
,
Pommier
,
Tdp1
,
TOP1
,
Topoisomerase 1B
,
Topotecan
,
Tyrosyl-DNA Phosphodiesterase 1
Category(s):
Collaboration Sou
g
ht > Licensing
,
Collaboration Sou
g
ht > Collaboration
,
TherapeuticArea > Oncolo
g
y
,
Application > Therapeutics
Sin
g
le Source-Detector Separation Approach to Calculate Tissue Oxygen Saturation
Summary: The National Institute of Child Health and Human Development (NICHD) seeks partners and/or licensees to further develop and commercialize the miniaturized tissue oximeter for implementin
g
the single source-detector separation algorithm in existing devices/systems to collect tissue oxygen saturation. Description of Technology: Tissue oxygen...
Published: 9/18/2024
|
Inventor(s):
Thien N
g
uyen
,
Amir
G
andjbakhche
,
Soon
g
ho Park
,
Brian Hill
Keywords(s):
Category(s):
Application > Medical Devices
,
Collaboration Sou
g
ht > Collaboration
,
TherapeuticArea > Respiratory
,
TherapeuticArea > Neurolo
g
y
,
TherapeuticArea > Infectious Disease
Improved Methods For Cryopreservation Of Cells, Tissues, And Or
g
ans
Summary: The National Eye Institute seeks research co-development partners and/or licensees for novel methods of cryopreservin
g
cells, tissues, and organs via FOXO1 activation and other mechanisms. Description of Technology: The cornea is a critical part of the eye that helps prevent debris from entering and refracts light for proper vision. Corneal...
Published: 9/9/2024
|
Inventor(s):
Jin
g
xing Ou
,
Kiyoharu Miya
g
ishima
,
G
uanghui Jin
,
Wei Li
,
Lihao
G
e
Keywords(s):
Category(s):
Application
,
Application > Research Materials
,
Collaboration Sou
g
ht > Collaboration
,
TherapeuticArea > Eye / Ear / Nose / Throat
Usin
g
Artificial Intelligence To Diagnose Uveitis
Summary: The National Eye Institute seeks research co-development partners and/or licensees for a deep learnin
g
algorithm that can identify retinal vasculitis using color fundus images. Description of Technology: Uveitis is caused by inflammation in the eye that can cause pain and reduce vision. The rate of uveitis in the United States is 1 in every...
Published: 8/14/2024
|
Inventor(s):
Shilpa Kodati
,
Jon
g
woo Kim
,
Nam N
g
uyen
Keywords(s):
Category(s):
Application > Dia
g
nostics
,
Collaboration Sou
g
ht > Collaboration
,
TherapeuticArea > Eye / Ear / Nose / Throat
Usin
g
Artificial Intelligence To Predict The Risk Of Age-Related Macular Degeneration
Summary: The National Eye Institute seeks research co-development partners and/or licensees for a deep learnin
g
algorithm that can predict the probability of progression to late age-related macular degeneration. Description of Technology: In 2024, an estimated 200 million people worldwide suffer from age-related macular degeneration (AMD); projected...
Published: 8/14/2024
|
Inventor(s):
Emily Chew
,
Zhiyon
g
Lu
,
Tiarnan Keenan
,
Wai Won
g
,
Qin
g
yu Chen
,
Elvira A
g
ron
Keywords(s):
Category(s):
Application > Dia
g
nostics
,
Collaboration Sou
g
ht > Collaboration
,
TherapeuticArea > Eye / Ear / Nose / Throat
TYROSINASE
G
ene Therapy for Oculocutaneous Albinism type 1A
Summary: The National Eye Institute seeks research co-development partners and/or licensees for an adeno-associated viral
g
ene therapy for Oculocutaneous Albinism type 1A. Description of Technology: Oculocutaneous albinism (OCA) is a genetically heterogeneous congenital disorder characterized by decreased or absent pigmentation in the hair,...
Published: 8/14/2024
|
Inventor(s):
Brian Brooks
,
Aman
G
eorge
Keywords(s):
Category(s):
Application
,
Application > Therapeutics
,
Collaboration Sou
g
ht > Collaboration
,
TherapeuticArea > Eye / Ear / Nose / Throat
,
TherapeuticArea > Rare / Ne
g
lected Diseases
,
TherapeuticArea > Ophthalmolo
g
y
Interleukin-27 Producin
g
B-Cell Population and Uses Thereof
Summary: The National Eye Institute (NEI) seeks research co-development partners and/or licensees to advance the production and uses of interleukin-27 (IL-27) producin
g
B-regulatory cell (i27-Breg) therapy for immune related autoimmune disorders. These disorders include but are not limited, to age-related macular degeneration (AMD), graft-versus-host...
Published: 8/14/2024
|
Inventor(s):
Charles E
g
wuagu
,
Jin Choi
Keywords(s):
Category(s):
Application > Therapeutics
,
Collaboration Sou
g
ht > Collaboration
,
TherapeuticArea > Eye / Ear / Nose / Throat
,
TherapeuticArea > Neurolo
g
y
,
TherapeuticArea > Immunolo
g
y
Usin
g
FDA-approved Small Molecule Drug Reserpine and related compounds (especially Halofantrine) To Protect Photoreceptors In Inherited Retinal Degenerations And Age-Related Macular Degeneration
Summary: The National Eye Institute seeks research co-development partners and/or licensees for a therapy usin
g
an FDA-approved small molecule drug reserpine (and related compounds especially halofantrine) that prevents photoreceptor cell death in retinal degenerations. Description of Technology: Inherited Retinal Degenerations (IRD), such as Leber...
Published: 9/18/2024
|
Inventor(s):
Anand Swaroop
,
Yu Holly Chen
,
Samantha Papal
,
Anupam Mondal
,
Manju Swaroop
,
Wei Zhen
g
,
G
regory Tawa
,
Wenwei Huan
g
,
Zhiji Luo
Keywords(s):
Category(s):
Application > Therapeutics
,
Collaboration Sou
g
ht > Collaboration
,
TherapeuticArea > Eye / Ear / Nose / Throat
Methods of Detectin
g
Loss of Heterozygosity and Damaging Mutations in Immune-Related Genes Using Liquid Biopsies
Summary: The National Cancer Institute (NCI) seeks co-development partners and/or licensees for a liquid biopsy dia
g
nostic assay capable of detecting loss of heterozygosity (LOH) and somatic mutations in genes important for antigen processing and presentation and interferon-γ response pathways. Description of Technology: Immunotherapy is...
Published: 7/26/2024
|
Inventor(s):
Scott Norber
g
,
Andrew Sinkoe
,
Xiaolin Wu
,
James
G
ulley
Keywords(s):
Category(s):
Application > Dia
g
nostics
,
Collaboration Sou
g
ht > Collaboration
,
TherapeuticArea > Oncolo
g
y
,
TherapeuticArea > Immunolo
g
y
Affinity Purified Polyclonal Antibody A
g
ainst Vangl2 (Van Gogh-like) as a Research Tool Product
This technolo
g
y includes an antibody that enables the identification and isolation of the protein and protein partners of Vangl2 for application by western blotting, immunoprecipitation and immunocytochemistry. Because planar cell polarity signaling disruption leads to direct or indirect pathologies including malformation of the neural tube, mental...
Published: 8/12/2024
|
Inventor(s):
Mireille Montcouquiol
Keywords(s):
Category(s):
Application > Research Materials
,
ResearchProducts > Antibodies
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3
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7
8
9
10
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