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Prematurely-Graying Mouse Line Demonstrates Regulation of Melanocyte Stem Cell Development by SOX10 (Sry-Related HMG-Box) Transcription Factor for Use in Regenerative Medicine
Case ID:
TAB-3671
Web Published:
12/6/2022
Description:
This technology includes transgenic mice to be used in the study of melanocyte stem cells (MSCs) for utilization in regenerative medicine. Using the melanocyte system as a model, we investigated establishment of MSCs in the hair bulge - the stem cell compartment of the hair. During embryogenesis, all melanoblasts express SOX10, but this expression is downregulated during hair follicle morphogenesis and MSC differentiation. To further study the role of SOX10, we generated transgenic mice overexpressing SOX10 in melanoblasts. In these mice, named Tg(DctSox10), SOX10 expression was controlled by the minimal promoter of dopachrome tautomerase (DCT), a gene whose protein product functions to regulate pigment synthesis and is used as a melanoblast marker. We found that SOX10 overexpression in the melanoblasts of Tg(DctSox10) heterozygous mice results in aberrant differentiation and ectopic pigmentation of cells residing in the hair bulge. Furthermore, Tg(DctSox10) homozygotes exhibit premature hair graying, attributable to the absence of MSCs and the consequential loss of melanocyte progeny that localize to the hair bulb.
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Direct Link:
https://nih.technologypublisher.com/tech/Prematurely-Graying_Mouse_Line_Demon strates_Regulation_of_Melanocyte_Stem_Cell_Development_by_SOX10_(Sry-Related _HMG-Box)_Transcription_Factor_for_Use_in_Regenerative_Medicine
Category(s):
Infectious Disease
Dental
Endocrinology
Oncology
Cardiology
Research Materials
Ophthalmology
Therapeutics
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For Information, Contact:
Eggerton Campbell
Licensing And Patenting Manager
NIH Technology Transfer
301-402-1648
eggerton.campbell@nih.gov
Inventors:
Melissa Harris
William ("Bill") Pavan
Keywords:
Cell
Demonstrates
Development
factor
HMG-Box
Line
Listed LPM Maddox as of 4/15/2015
Melanocyte
Mouse
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
Prematurely-Graying
REGULATION
RXXXXX
SOX10
Sry-Related
Stem
transcription
VPXXXX
WIXXXX
XEXXXX
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