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High-Titer, Fast-Growth Chimeric Dengue/West Nile Viruses for Vaccine and Diagnostics Development
Case ID:
TAB-2889
Web Published:
12/6/2022
Description:
Mosquito-transmitted dengue virus is one of the leading causes of illness in the tropics and subtropics. There is currently no vaccine available and a number of DENV diagnostic and research applications depend on the production of large amounts of these viruses. However, due to the slow growing nature of DENVs these protocols are very time-consuming.
Researchers at the CDC have engineered stable, rapidly growing dengue-like viruses by combining the fast replicative ability of the West Nile virus with the immunogenic premembrane and envelope surface proteins of DENV serotypes 1, 2, 3, and 4, respectively. These DENV structural features are involved in a number of biological functions including virus-cell attachment and initiation of virus-specific antibody production. In turn, the chimeric viruses are more infectious and virulent than wild type DENV, but they do respond similarly in neutralization assays. The investigators also describe methods to use the inactivated form of these chimeras to elicit protective immune responses. Thus, these chimeric viruses can be used to enhance the efficiency of DENV diagnostics, vaccine development and testing, and basic dengue virology.
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Direct Link:
https://nih.technologypublisher.com/tech?title=High-Titer%2c_Fast-Growth_Chim eric_Dengue%2fWest_Nile_Viruses_for_Vaccine_and_Diagnostics_Development
Category(s):
Licensing
Therapeutics
Vaccines
Infectious Disease
Diagnostics
Research Materials
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For Information, Contact:
Jeremiah Mitzelfelt
NIH Technology Transfer
301-443-8518
jeremiah.mitzelfelt@nih.gov
Inventors:
Claire Kinney
Keywords:
chimeric
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DC5XXX
DDXXXX
Dengue-Like
ENGINEERING
Fast-Growth
NILE/DENGUE
Viruses
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WBXXXX
West
WIXXXX
XEXXXX
YBXXXX
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