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Murine Models of an Autoinflammatory Disease, Familial Mediterranean Fever (FMF), to Study the Pathophysiology of Inherited Disorders of Inflammation and Evaluate New Therapies
Case ID:
TAB-3630
Web Published:
12/6/2022
Description:
This technology includes mouse models (heterozygous for the knock-in (KI) and homozygous for the knock-out (KO)) to be used as research reagents and to study molecular mechanisms and potential therapies for Familial Mediterranean fever (FMF). FMF is the prototype of a group of inherited disorders characterized by recurring, spontaneous episodes of fever and localized inflammation. The gene responsible for FMF is composed of 10 exons encoding a 781 amino acid protein known as pyrin. In addition to FMF, some recent findings show that an abnormal activation of the pyrin inflammasome is the inflammation inducing factor for seemingly distinct autoinflammatory disorder, hyperimmunoglobulinemia D syndrome, and a mutation in pyrin is also a genetic risk factor for pyrin-associated autoinflammation and neutrophilic dermatosis. Thus, these murine models may be used to evaluate other autoinflammatory disorders in addition to FMF.
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Direct Link:
https://nih.technologypublisher.com/tech?title=Murine_Models_of_an_Autoinflam matory_Disease%2c_Familial_Mediterranean_Fever_(FMF)%2c_to_Study_the_Pathoph ysiology_of_Inherited_Disorders_of_Inflammation_and_Evaluate_New_Therapies
Category(s):
Therapeutics
Research Materials
Oncology
Dental
Ophthalmology
Cardiology
Endocrinology
Infectious Disease
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For Information, Contact:
Eggerton Campbell
Licensing And Patenting Manager
NIH Technology Transfer
301-402-1648
eggerton.campbell@nih.gov
Inventors:
Jae Chae
Daniel ("Dan") Kastner
Keywords:
Autoinfla~-~atory
Autoinflamatory
Disease
FAMILIAL
FEVER
FMF
MEDITERRANEAN
Models
Murine
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WIXXXX
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