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Novel NMDA ligands that are specific and selective to the NR2B subunits based on the derivatives of 7-methoxy-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol
Case ID:
TAB-3685
Web Published:
12/6/2022
Description:
This invention includes the design and synthesis of ligands that bind selectively and specifically to the NR2B subunit of the NMDA receptor. The NMDA receptor is thought to play a role in the pathophysiology of psychiatric disorders, including depression, stroke, drug addiction, and neuropathic pain. Existing ligands to the NMDA receptor are widely used to treat these conditions.
Researchers at the National Institute of Mental Health (NIMH) have synthesized new ligands based on the 7-methoxy-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol molecule. Binding affinities were checked, and candidate ligands were radiolabeled with an 11C isotope. The radiolabeled compounds were evaluated by PET (positron emission tomography) imaging in rodents. The PET imaging showed that these radioligands bind selectively and specifically to the NR2B receptor.
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Direct Link:
https://nih.technologypublisher.com/tech?title=Novel_NMDA_ligands_that_are_sp ecific_and_selective_to_the_NR2B_subunits_based_on_the_derivatives_of_7-meth oxy-3-(4-phenylbutyl)-2%2c3%2c4%2c5-tetrahydro-1H-benzo%5bd%5dazepin-1-ol
Category(s):
Research Materials
Psychiatry/Mental Health
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For Information, Contact:
Anton Dawson
Technology Transfer and Patent Specialist
NIH Technology Transfer
301-496-6784
anton.dawson@nih.gov
Inventors:
Victor Pike
Lisheng Cai
Keywords:
3
4
5-tetrahydro-1H-benzo[d]azepin-1-ol
7-methoxy-3-4-phenylbutyl-2
Based
Derivatives
LIGANDS
NR2B
VNXXXX
WIXXXX
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