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Prevention or Treatment of Viral Infections by Inhibition of the Histone Methyltransferases EZH1/2
Case ID:
TAB-2969
Web Published:
12/6/2022
Description:
Herpes simplex viral infections, including herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), are exceptionally common worldwide. These viruses establish lifelong persistent infections with cycles of lytic reactivation to produce recurrent diseases including oral and genital lesions, herpetic keratitis/blindness, congenital-developmental syndromes, and viral encephalitis. Infection with HSV-2 increases the rate of human immunodeficiency virus (HIV) transmission in coinfected individuals. DNA replication inhibitors are typically used to treat herpesvirus infections. However, these compounds do not completely suppress infection, viral shedding, reactivation from latency, and the inflammation that contributes to diseases such as keratitis. An unmet need continues to exist for methods of preventing or treating herpesviral infections. The application claims methods of preventing or treating herpesviral infection of a host, comprising administering to the host an effective amount of an inhibitor of the EZH1/2 histone methyltransferase activities. The application is not limited to herpes simplex virus but rather is applicable to other viral infections as well.
Patent Information:
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Patent No.
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Direct Link:
https://nih.technologypublisher.com/tech?title=Prevention_or_Treatment_of_Vir al_Infections_by_Inhibition_of_the_Histone_Methyltransferases_EZH1%2f2
Category(s):
Licensing
Therapeutics
Vaccines
Infectious Disease
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For Information, Contact:
Benjamin Hurley
Office of Technology Transfer Center
NIH Technology Transfer
240-669-5092
benjamin.hurley@nih.gov
Inventors:
Jesse Arbuckle
Thomas Kristie
Keywords:
DB4BXX
DB4XXX
DBXXXX
DC5BXX
DC5XXX
DCXXXX
DEXXXX
DXXXXX
EZH1/2
HERPESVIRUS
Infection
Inhibitors
Latency
Listed LPM Fenn as of 4/15/2015
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
Reactivation
Suppresses
VLXXXX
WKXXXX
WNXXXX
XKXXXX
YBXXXX
YCXXXX
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