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Systems and Methods to Automatically Detect Ellipsoid Zone Loss in SD-OCT Imaging
Summary: The National Eye Institute (NEI) seeks research co-development partners and/or licensees for an automatic deep learning-based algorithm to detect and quantitate ellipsoid zone (EZ) loss in Spectral Domain Optical Coherence Tomography (SD-OCT) images. Description of Technology: The present disclosure generally relates a method of automatically...
Published: 3/11/2026
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Inventor(s):
Wathudurage De Silva
,
Catherine Cukras
Keywords(s):
Category(s):
Application > Software / Apps
,
TherapeuticArea
,
TherapeuticArea > Ear, Nose, & Throat
,
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
MODIFIED PIGMENT EPITHELIUM-DERIVED FACTOR PEPTIDES AND METHODS OF USE
Summary: The National Eye Institute (NEI) seeks research co-development partners and/or licensees for the development of an eyedrop formulation to deliver a series of peptides as a gene-agnostic approach to treating inherited retinal diseases. Description of Technology: Retinitis pigmentosa (RP) is one of the most common inherited retinal diseases...
Published: 3/11/2026
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Inventor(s):
S. Patricia Becerra
,
Rolf Swenson
,
Natarajan Raju
,
Alexandra Bernardo-Colon
,
Carolyn Woodroofe
,
Burchelle Blackman
Keywords(s):
Category(s):
Application > Therapeutics
,
TherapeuticArea > Ear, Nose, & Throat
,
TherapeuticArea > Ophthalmology
,
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
Real-time AI System for Echocardiography Analysis and Quantification
Summary: We are seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize this technology. Description of Technology: Scientists have developed an artificial intelligence (AI) system to automatically extract predictive biomarkers from echocardiography. This AI system...
Published: 2/18/2026
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Inventor(s):
Ghada Alzamzmi
,
Sameer Antani
,
Li-Yueh Hsu
,
Vandana Sachdev
,
Sivarama Krishnan Rajaraman
Keywords(s):
Category(s):
Application > Diagnostics
,
TherapeuticArea > Cardiology
,
Collaboration Sought > Collaboration
,
Application > Software / Apps
Humanized 40H3 Antibody
Summary: The NCI seeks research co-development partners or licensees for monoclonal antibodies that specifically target cancer-expressed EGFR. Description of Technology: Epidermal growth factor receptor (EGFR) is a well-known oncogenic driver in lung cancer, head and neck cancer, glioblastoma multiforme (GBM) and other cancers. NCI inventors have...
Published: 2/5/2026
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Inventor(s):
David Fitzgerald
,
Antonella Antignani
,
Robert Sarnovsky
Keywords(s):
Category(s):
TherapeuticArea > Oncology
,
Application > Therapeutics
,
Collaboration Sought > Licensing
,
Collaboration Sought > Collaboration
Humanized Monoclonal Antibodies Specific Against Human Soluble Tissue Factor (hsTF) as Diagnosis, Prevention and Therapeutic Agents for Thrombosis
Summary: The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a novel humanized monoclonal antibody (58B3) that selectively targets a newly identified soluble Tissue Factor (sTF) to diagnose, prevent and treat pathological thrombosis associated with inflammation, viral/bacterial infection, sepsis and cancer...
Published: 2/11/2026
|
Inventor(s):
Zheng-gang Liu
,
Swati Choksi
,
PeiXing Wan
Keywords(s):
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Immunology
,
TherapeuticArea > Infectious Disease
,
TherapeuticArea > Oncology
,
Application > Diagnostics
,
Application > Therapeutics
Identification and Characterization of HLA-A24 Agonist Epitopes of MUC1 Oncoprotein
Summary: The National Cancer Institute (NCI) seeks co-development partners and licensees for a human cytotoxic T lymphocyte agonist epitope from the C-terminal subunit of mucin 1 (MUC1-C), which can be used as a peptide, polypeptide (protein), in a cancer vaccine or T-cell targeted therapy to target many tumor types. Description of Technology: Many...
Published: 9/29/2025
|
Inventor(s):
Jeffrey Schlom
,
Kwong-Yok Tsang
Keywords(s):
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
Application > Therapeutics
,
TherapeuticArea > Immunology
,
TherapeuticArea > Oncology
Novel Human Immunogenic Epitopes of the Human Endogenous Retrovirus ERVMER34-1
Summary: The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for the clinical translation of novel peptide-based therapeutic cancer vaccines derived from ERVMER34-1, a human endogenous retrovirus (HERV) antigen, offering a unique opportunity to address a significant unmet need in the treatment of various carcinomas. Description...
Published: 9/29/2025
|
Inventor(s):
Jeffrey Schlom
,
Duane Hamilton
,
Claudia Palena
,
Renee Donahue
Keywords(s):
Category(s):
TherapeuticArea > Immunology
,
TherapeuticArea > Oncology
,
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
Application > Vaccines
Chimeric Antigen Receptors Targeting the Gamma Delta (γδ) T-Cell Receptor
Summary: The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a set of Chimeric Antigen Receptors (CARs) that target the γδ T-Cell Receptor. Description of Technology: T cells express two main types of receptors based on the proteins that make up the T-cell receptor (TCR) heterodimers: ab (alpha...
Published: 8/25/2025
|
Inventor(s):
James Kochenderfer
,
Lauren Cutmore
Keywords(s):
Category(s):
TherapeuticArea > Oncology
,
TherapeuticArea > Immunology
,
Application > Therapeutics
,
Collaboration Sought > Licensing
,
Collaboration Sought > Collaboration
Method of Manufacturing Papilloma Infiltrating Lymphocyte (PIL) Cell Therapy Products as a Treatment for Patients with Chronic Viral Infection(s)
Summary: The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for development of papilloma-infiltrating lymphocytes (PIL) as treatment for patients with chronic human papillomavirus (HPV) 6 or 11 infections. Description of Technology: Recurrent Respiratory Papillomatosis (RRP) and anogenital condyloma are caused...
Published: 8/21/2025
|
Inventor(s):
Scott Norberg
,
Clint Allen
,
Zulmarie Franco
,
Ke Bai
Keywords(s):
Category(s):
Application > Therapeutics
,
TherapeuticArea > Infectious Disease
,
TherapeuticArea > Immunology
,
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
Method of Detecting Circulating Cell-Free HPV 6 and 11 DNA in Patients Afflicted With Diseases Caused by Chronic HPV 6 or 11 Infection and Use Thereof
Summary: The National Cancer Institute (NCI) and Frederick National Laboratory for Cancer Research (FNLCR) seek research co-development partners and/or licensees for commercial development of a novel liquid biopsy diagnostic for non-invasive detection of cell-free HPV 6 and 11 DNA for recurrent respiratory papillomatosis (RRP). Description of Technology: Recurrent...
Published: 10/7/2025
|
Inventor(s):
Scott Norberg
,
Clint Allen
,
Xiaolin Wu
Keywords(s):
Category(s):
TherapeuticArea > Infectious Disease
,
TherapeuticArea > Oncology
,
TherapeuticArea > Pulmonology
,
Application > Diagnostics
,
Collaboration Sought > Licensing
,
Collaboration Sought > Collaboration
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