Search Results - ResearchProducts+%3e+Plasmids%2fVectors

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Application of AAV2.7m8 in Inner Ear Therapeutics

This technology includes a viral vector for delivering gene therapy to the inner ear as a treatment for hearing loss and dizziness. We have found that AAv2.7m8 is able to infect multiple cell types in the mammalian inner ear with high efficiency.

Published: 8/12/2024 | Inventor(s): Wade Chien, Jean Bennett

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, ResearchProducts > Plasmids/Vectors

Generation of AAVS1 and C13 “Safe Harbor” Transcription Activator-life Effector Nucleases (TALENs) for Drug Screening or Gene Therapy Development

This technology includes AAVS1 and C13 “safe harbor” transcription activator-life effector nucleases (TALENs) for drug screening or gene therapy applications. TALENs are engineered sequence-specific DNA endonucleases that can significantly enhance genome-editing efficiency by >100-1000 folds. “Safe harbor” such as AAVS1 safe...

Published: 9/10/2024 | Inventor(s): Jizhong Zou, Mahendra Rao

Keywords(s):

Category(s): Application > Diagnostics, Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Plasmids/Vectors

Generation of Safe-harbor Gene Targeting Donor Plasmids

This technology includes two safe harbor gene targeting donors, specifically designed for applications in the study of induced pluripotent stem cells (iPSC). These include the pAAVS1D-CMV.RFP-EF1a.copGFPpuro and pAAVS1-iCLHN donors. A key feature of these donors is their ability to integrate various transgenes into specific loci through homologous recombination,...

Published: 9/10/2024 | Inventor(s): Jizhong Zou, Mahendra Rao

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Materials Available, ResearchProducts > Human iPSC Lines, ResearchProducts > Plasmids/Vectors

Conditional Cell Immortalization Plasmid for Basic Science Research

This technology includes a novel plasmid design for cell immortalization. It uniquely combines the conditional activation of human telomerase and c-myc genes through cumate addition, a method distinct from traditional immortalization techniques which commonly use SV40 T-antigen, telomerase, or c-myc. This plasmid also includes a GFP reporter and a puromycin...

Published: 8/12/2024 | Inventor(s): Nasir Malik

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Materials Available, ResearchProducts > Plasmids/Vectors

Clonal Spodoptera Frugiperda Cell lines for Enhanced Expression

This technology includes Spodoptera frugiperda (Sf9) cells which were developed to produce recombinant adeno-associated virus. The cells maintain a copy of the vector genome and for production, require infection with a single baculovirus that expresses either structural and nonstructural proteins to produce rAAV, or the non-structural (Rep) proteins...

Published: 8/12/2024 | Inventor(s): Lina Li, Robert Kotin

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Plasmids/Vectors

Cas9 Protein Delivery with Lentiviral Vector Particles as a Therapy for Sickle Cell Disease

This technology includes efficient lentiviral gene delivery system for both guide RNA and Cas9 endonuclease as a method to cure sickle cell disease. Gene correction is an ideal gene therapy strategy for hereditary disease, including sickle cell disease. To deliver both guide RNA and Cas9 endonuclease into target cells, we used HIV-l based lentiviral...

Published: 8/12/2024 | Inventor(s): Naoya Uchida, Juan Haro Mora, John Tisdale

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Plasmids/Vectors

Cytochrome P450 CYP2J Polyclonal Antibodies and Recombinant Proteins for Immunoblotting and Metabolism Studies

This technology includes identified members of the mouse cytochromes P450 CYP2J subfamily and antibodies to them for P450 expression studies and metabolism research. Recombinant proteins of the CYP2J subfamily members have also been expressed. The CYP2J subfamily members have a wide tissue distribution and may be useful as model systems for studies...

Published: 8/12/2024 | Inventor(s): Joan Graves, Darryl Zeldin, Joyce Goldstein, Jennifer Bradbury, Joyce Blaisdell

Keywords(s):

Category(s): Application > Research Materials, ResearchProducts > Antibodies, ResearchProducts > Plasmids/Vectors, TherapeuticArea > Metabolic Disease

Treatment of the beta-globinopathies through inhibition of RIOK3 activity

Disorders of adult beta-globin synthesis, which include sickle cell disease (SCD) and beta-thalassemia, are the most common monogenic disorders in the world. While the curative potential of bone marrow transplantation has been demonstrated, this approach is limited to a small fraction of affected patients due to the requirement for an HLA-matched donor,...

Published: 4/8/2024 | Inventor(s): John Tisdale, Bjorg Gudmundsdottir, Laxminath Tumburu

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Immunology, ResearchProducts > Plasmids/Vectors