Search Results - application+%3e+diagnostics

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Methods of Detecting Loss of Heterozygosity and Damaging Mutations in Immune-Related Genes Using Liquid Biopsies

Summary: The National Cancer Institute (NCI) seeks co-development partners and/or licensees for a liquid biopsy diagnostic assay capable of detecting loss of heterozygosity (LOH) and somatic mutations in genes important for antigen processing and presentation and interferon-γ response pathways. Description of Technology: Immunotherapy is...

Published: 9/13/2024 | Inventor(s): Scott Norberg, Andrew Sinkoe, Xiaolin Wu, James Gulley

Keywords(s):

Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Immunology

Using Artificial Intelligence To Diagnose Uveitis

Summary: The National Eye Institute seeks research co-development partners and/or licensees for a deep learning algorithm that can identify retinal vasculitis using color fundus images. Description of Technology: Uveitis is caused by inflammation in the eye that can cause pain and reduce vision. The rate of uveitis in the United States is 1 in every...

Published: 8/14/2024 | Inventor(s): Shilpa Kodati, Jongwoo Kim, Nam Nguyen

Keywords(s):

Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat

Using Artificial Intelligence To Predict The Risk Of Age-Related Macular Degeneration

Summary: The National Eye Institute seeks research co-development partners and/or licensees for a deep learning algorithm that can predict the probability of progression to late age-related macular degeneration. Description of Technology: In 2024, an estimated 200 million people worldwide suffer from age-related macular degeneration (AMD); projected...

Published: 8/14/2024 | Inventor(s): Emily Chew, Zhiyong Lu, Tiarnan Keenan, Wai Wong, Qingyu Chen, Elvira Agron

Keywords(s):

Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat

Methods of Detecting Loss of Heterozygosity and Damaging Mutations in Immune-Related Genes Using Liquid Biopsies

Published: 7/26/2024 | Inventor(s): Scott Norberg, Andrew Sinkoe, Xiaolin Wu, James Gulley

Keywords(s):

Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Immunology

Immunoassay-derived Protein Biomarkers of Atherosclerotic Cardiovascular Disease Risk

This technology includes a combination of 6 protein biomarkers and clinical risk factors to be used as an In Vitro Diagnostic Multivariate Index Assay (IVDMIA) that can improve the identification of individuals at high risk for atherosclerotic cardiovascular disease (ASCVD). Incorporation of novel protein biomarkers of ASCVD risk into risk assessment...

Published: 8/12/2024 | Inventor(s): Daniel Levy, Martin Larson, Ralph D'Agostino

Keywords(s):

Category(s): Application > Diagnostics, Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Cardiology

Bivalent Tn5 Complex and its Application to Map Enhancer-Promoter Interactions for Use in Diagnostics

This technology includes a new reagent, termed bivalent Tn5 complex, and applied it to mapping genome-wide enhancer-promoter interactions to be utilized for disease diagnostics. Chromatin structure is critical for regulating transcription in normal development and disease states. In particular, the interaction between enhancers and promotes are essential...

Published: 8/12/2024 | Inventor(s): Keji Zhao, Qingsong Tang

Keywords(s):

Category(s): Application > Diagnostics, Collaboration Sought > Licensing, ResearchProducts > Research Equipment

PET Imaging of lntegrin Expression with Suitably Labeled RGD Peptides for Multiple Diagnostic Purposes

This technology includes a number of dimeric RGD peptides which been developed and labeled with various PET isotopes (1BF, 68Ga, and 64Cu) for imaging integrin expression in cancer, inflammation, rheumatoid arthritis, myocardial infarct, stroke and traumatic injury. A number of these peptides have been translated into clinic for diagnosis and therapy...

Published: 8/12/2024 | Inventor(s): Xiaoyuan (Shawn) Chen, Lixin Lang, Gang NIU

Keywords(s):

Category(s): Application > Diagnostics, Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, TherapeuticArea > Immunology, TherapeuticArea > Neurology

Background-free Imaging by Selective Modulation of Nanodiamond Fluorescence Using a Magnetic Field

This technology includes the use of nanodiamonds to achieve background-free imaging. We present several techniques to reduce or eliminate background florescence by exploiting properties of the fluorescent nanodiamonds. In particular, magnetic field modulation of the fluorescence intensity offers a simple, robust, and easily adaptable method to obtain...

Published: 8/12/2024 | Inventor(s): Ambika Bumb, Susanta Sarkar, Keir Neuman

Keywords(s):

Category(s): Application > Diagnostics, Application > Medical Devices, Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment

A Highly Efficient Differentiation Protocol for Placental Cells Derived from Human Pluripotent Stem Cells for Diagnostic and Therapeutic Applications

This technology includes in vitro-generated trophectoderm (TE) cells, which are ideal for modeling diseases of the placenta, drug screening, and cell-based therapies. The TE lineage which gives rise to placental cells during early human development. Derivation of definitive placental cells from human pluripotent stem cells in culture remains controversial...

Published: 8/12/2024 | Inventor(s): William Havel, Jeremy Newkirk, Rita Hadley, Yun Zhou

Keywords(s):

Category(s): Application > Diagnostics, Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Human Cell Lines, ResearchProducts > Human iPSC Lines

High Relaxivity Mulitivalent Gadolinium on a Peptide Scaffold for Targeted MRI Applications in Disease Diagnosis

This technology includes a peptide containing alternating Alanine and Lys(DOTA-Gd) residues can be used to increase the MRI relaxivity of a peptide. The low molecular weight construct can be appended to proteins, antibodies and peptides to increase MRI signals. This approach offers advantages over previous dendrimeric constructs. The increased MRI signal...

Published: 8/12/2024 | Inventor(s): Rolf Swenson, Alan Koretsky, Nikorn Pothayee, Deepak Sail

Keywords(s):

Category(s): Application > Diagnostics, Application > Medical Devices, Application > Research Materials, Collaboration Sought > Licensing

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