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Transgenic Mice Expressing Human Arginase II Gene in Endothelium: Useful for Studying Atherosclerosis and Other Vasculopathies

Cardiovascular disorders associated with endothelial dysfunction, like atherosclerosis, have decreased endothelial nitric oxide (NO) bioavailability. L-arginine, the primary substrate for endothelial nitric oxide synthase (eNOS), is important in the regulation of NO production. Arginase competes with eNOS for L-arginine and has been implicated in...

Published: 10/28/2024 | Inventor(s): Alan Remaley, Boris Vaisman

Keywords(s): 2, AC5XXX, ACXXXX, Arginase, AXXXXX, DDXXXX, DXXXXX, Endothelial, FUNCTION, Gene, Model, Mouse, Novel, Role, RXXXXX, STUDIES, That

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Research Materials