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Endothelial Cell Line to Study Prevention of Atherosclerosis

Atherosclerosis underlies most cases of cardiovascular disease (CVD), which is now the major cause of morbidity and mortality in developed countries. An inflammatory reaction is an essential component in the appearance and development of an atherosclerotic lesion. The inflammatory process is associated with the expression of adhesion molecules such...

Published: 7/25/2024 | Inventor(s): Alan Remaley

Keywords(s): Cell, Development, Endothelial, IDXXXX, IXXXXX, REPORTER, System

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Research Materials, Application > Diagnostics

Transgenic Mice Expressing Human Arginase II Gene in Endothelium: Useful for Studying Atherosclerosis and Other Vasculopathies

Cardiovascular disorders associated with endothelial dysfunction, like atherosclerosis, have decreased endothelial nitric oxide (NO) bioavailability. L-arginine, the primary substrate for endothelial nitric oxide synthase (eNOS), is important in the regulation of NO production. Arginase competes with eNOS for L-arginine and has been implicated in...

Published: 7/25/2024 | Inventor(s): Alan Remaley, Boris Vaisman

Keywords(s): 2, AC5XXX, ACXXXX, Arginase, AXXXXX, DDXXXX, DXXXXX, Endothelial, FUNCTION, Gene, Model, Mouse, Novel, Role, RXXXXX, STUDIES, That

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Research Materials

Method for the Diagnosis and Treatment of Vascular Disease

Cardiovascular disease is a major health risk throughout the industrialized world. Atherosclerosis, the most prevalent of cardiovascular diseases, is the principal cause of heart attack, stroke, and gangrene of the extremities. It is also the principal cause of death in the United States. This invention portrays a method for diagnosing decreased vascular...

Published: 7/25/2024 | Inventor(s): Arshed Quyyumi, Jonathan Hill, Toren Finkel

Keywords(s): Cells, Diagnosis, Disease, Endothelial, IAXXXX, IXXXXX, Listed LPM Nguyen-Antczak as of 4/15/2015, Method, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Progenitor, treatment, vascular

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics