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Surgical Tool for Sub-retinal Tissue Implantation

Abstract: The accurate placement of transplanted tissue at a precise position in the retina is difficult but critical for a successful implementation of an ocular surgical intervention. Researchers at the National Eye Institute (NEI) developed a surgical tool (see image below) designed to place tissue patches, such as sheets of tissue, onto the retina...

Published: 4/8/2024 | Inventor(s): Arvydas Maminishkis

Keywords(s): EYE, Intra-Ocular, Maminishkis, National Eye Institute, NEI, sub-retinal, surgical tool, tissue placement retina

Category(s): Collaboration Sought > Licensing, Application > Non-Medical Devices, Application > Medical Devices, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

Methods and Compositions for Treating Genetically Linked Diseases of the Eye

Abstract: X-linked retinoschisis (XLRS) is an inherited, monogenetic ocular disease caused by mutations in the retinoschisin (RS1) gene, resulting in the development of cystic cavities throughout the retina and leading to juvenile macular degeneration. Approximately 1:15,000 males in the US are affected, classifying the condition as an orphan indication. The...

Published: 4/8/2024 | Inventor(s): Paul Sieving, Ronald Bush, Yong Zeng, Peter Colosi

Keywords(s): Clinical, EYE, GENE THERAPY, ophthalmological, Orphan Indication, Sieving, XLRS

Category(s): TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Collaboration Sought > Licensing, Application > Therapeutics

Ex-vivo Production of Regulatory B-Cells for Use in Auto-immune Diseases

Abstract: Regulatory B-cells (Breg) play an important role in reducing autoimmunity and reduced levels of these cells are implicated in etiology of several auto-inflammatory diseases. Despite their impact in many diseases, their physiological inducers are unknown. Given that Bregs are a very rare B-cell, identifying factors that promote their development...

Published: 8/14/2024 | Inventor(s): Charles Egwuagu, Ren-Wi Wang, Chengrong Yu

Keywords(s): ARTHRITIS, B-CELL, COLITIS, EYE, Multiple sclerosis, sarcoidosis

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology