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Use of Heterodimeric IL-15 in Adoptive Cell Transfer

Abstract: Adoptive cell transfer (ACT) is a promising immunotherapeutic approach for cancer treatment. During ACT, if a patient is subjected to lymphodepletion prior to cell transfer, there is an observed improvement in a patient’s response to treatment. However, lymphodepletion is associated with detrimental effects, including severe immune dysfunction...

Published: 5/22/2024 | Inventor(s): George Pavlakis, Barbara Felber, Christina Bergamaschi

Keywords(s): act, Adoptive Cell Transfer, HetIL-15, IL-15, Immunotherapy, Interleukin 15, Lymphodepletion, Receptor Alpha Complex

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology