Search Results - christina+bergamaschi

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Use of Heterodimeric IL-15 in Adoptive Cell Transfer

Abstract: Adoptive cell transfer (ACT) is a promising immunotherapeutic approach for cancer treatment. During ACT, if a patient is subjected to lymphodepletion prior to cell transfer, there is an observed improvement in a patient’s response to treatment. However, lymphodepletion is associated with detrimental effects, including severe immune dysfunction...

Published: 5/22/2024 | Inventor(s): George Pavlakis, Barbara Felber, Christina Bergamaschi

Keywords(s): act, Adoptive Cell Transfer, HetIL-15, IL-15, Immunotherapy, Interleukin 15, Lymphodepletion, Receptor Alpha Complex

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

Bile Acids and Other Agents that Modulate the Gut Microbiome for the Treatment of Liver Cancer

Abstract: Primary liver tumors and secondary hepatic malignancies are among the leading causes of cancer-related deaths. Liver metastases account for 95% of all hepatic cancers, and the liver is the most common site for organ metastasis in the body. The gut microbiome serves an important role in antitumor immunity regulating the efficacy of chemo- and...

Published: 4/8/2024 | Inventor(s): Tim Greten, Chi Ma

Keywords(s): Bile Acid, Greten, Liver cancer, Natural Killer T Cells, NKT cells

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing