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Creation of a High-density Screening Format and the Identification of Small Molecule Inhibitors of the SIX/EYA Interaction for the Treatment of Cancers
The technology includes the creation of a high-throughput assay and the identification and use of small molecules that inhibit the SIX/EYA interaction as a treatment for cancer. The Eya proteins are phosphatases that form a complex and are activated by the Six family of homeobox transcription factors. The interaction of Eya and Six mediates breast cancer...
Published: 7/25/2024
|
Inventor(s):
Marc Ferrer-Alegre
,
Xin Hu
,
Juan Marugan
,
Lesley Mathews
,
Heide Ford
,
Melanie Blevins
,
Rebecca Mull
,
Rui Zhao
Keywords(s):
cancers
,
Identification
,
Identifying
,
Inhibitors
,
INTERACTION
,
Listed LPM Vathyam as of 4/15/2015
,
Method
,
MOLECULE
,
Post LPM Assignment Set 20150420
,
Pre LPM working set 20150418
,
SIX/EYA
,
Small
,
treatment
,
VCXXXX
,
WIXXXX
,
WKXXXX
,
XEXXXX
Category(s):
Application > Research Materials
,
Application > Therapeutics
,
TherapeuticArea > Oncology
Potentiating Antibody Therapy by Targeting Complement Deposited on Cancer Cells
Monoclonal antibodies (mAbs) have become a mainstay of therapy for many cancers. However, antibody therapy is not completely effective in some applications due to loss of the target surface antigen on cancer cells. Such mAb-induced “escape variants” are no longer sensitive to the therapeutic mAb therapy. It was observed that the escape variants carried...
Published: 7/25/2024
|
Inventor(s):
Martin Skarzynski
,
Margaret Lindorfer
,
Ronald Taylor
,
Christoph Rader
,
Berengere Vire
,
Erika Gaglione
,
Haiyong Peng
,
Sivasubramanian Baskar
,
Adrian Wiestner
Keywords(s):
2JXXXX
,
4GXXXX
,
5OXXXX
,
ANTIBODY
,
C3
,
C3d
,
CANCER
,
CB1XXX
,
Cell
,
Cells
,
Complement
,
Deposited
,
Listed LPM Vathyam as of 4/15/2015
,
Patent Category - Biotechnology
,
Post LPM Assignment Set 20150420
,
Potentiating
,
Pre LPM working set 20150418
,
Protein
,
Surface
,
Targeting
,
THERAPY
,
THEROF
,
VCXXXX
Category(s):
Collaboration Sought > Licensing
,
Application > Therapeutics
,
TherapeuticArea > Oncology
,
TherapeuticArea > Immunology
Efficient mRNA-Based Genetic Engineering of Human NK Cells with High-Affinity CD16 and CCR7
A highly efficient method to genetically modify natural killer (NK) cells to induce expression of high affinity CD16 (HA-CD16) through mRNA electroporation, to potentiate NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC). ADCC is mediated by CD16+ NK cells following adoptive NK cell transfer, but most humans express CD16 which has a relatively...
Published: 7/25/2024
|
Inventor(s):
Mattias Carlsten
,
Richard Childs
Keywords(s):
ADCC
,
antibodies
,
ANTIBODY
,
CBXXXX
,
CD16
,
ex vivo
,
Listed LPM Vathyam as of 4/15/2015
,
monoclonal
,
NK
,
NK Cells
,
Patent Category - Biotechnology
,
Post LPM Assignment Set 20150420
,
Pre LPM working set 20150418
,
TRANSFECTION
,
TUMORS
,
VCXXXX
,
WJXXXX
,
XEXXXX
,
YAXXXX
,
YBXXXX
Category(s):
Collaboration Sought > Licensing
,
Application > Therapeutics
,
TherapeuticArea > Oncology
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