Search Results - o%e2%80%99keefe

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Anti-Viral Polypeptide Griffithsin: Compounds, Compositions, and Methods of Use

Abstract: This technology describes additional methods of using the griffithsin anti-viral polypeptides described in related NCI invention (reference number E-106-2003). Specifically, this invention describes the use of GRFT to inhibit viral infection of hepatitis C viral infection, a severe acute respiratory syndrome (SARS) viral infection, an H5N1...

Published: 4/8/2024 | Inventor(s): Barry O'Keefe, James McMahon, Toshiyuki Mori

Keywords(s): Anti-Viral, Corona virus, Ebola, Griffithsin, INFLUENZA, O’Keefe, SARS

Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Collaboration, Application > Therapeutics, Collaboration Sought > Licensing

Enhanced Cancer Chemotherapy Using the Bioactive Peptide Recifin And Its Analogues

Abstract: Topoisomerase enzymes play an important role in cancer progression by controlling changes in DNA structure through catalyzing the breaking and rejoining of the phosphodiester backbone of DNA strands during the normal cell cycle. Therefore, topoisomerases are important targets for cancer chemotherapy. Many topoisomerase 1 (TOP1) inhibitors...

Published: 4/8/2024 | Inventor(s): Barry O'Keefe, Lauren Krumpe, Johan Rosengren, Ingrid Schroeder, Alan Bermingham, Christophe Marchand, Kirk Gustafson, Brice Wilson, Yves Pommier

Keywords(s): CANCER, Chemosensitizing Agents, CHEMOTHERAPY, Cyclic Peptide, Irinotecan TOP1, O’Keefe, Recifin, Tdp1, Topoisomerase 1 inhibitors, Topotecan, Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics

Scytovirin Domain 1 Related Polypeptides

Abstract: Despite therapeutic advances, human immunodeficiency virus (HIV) is still a pervasive disease, with approximately 37 million people infected worldwide. Peptides have become popular therapeutic agents, as these proteins offer structural diversity for many different diseases. Several peptides were commercially developed as HIV therapeutics,...

Published: 4/8/2024 | Inventor(s): Barry O'Keefe, Chang-yun Xiong, James McMahon, R. Andrew Byrd

Keywords(s): HIV, O’Keefe, POLYPEPTIDES, Scytovirin

Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Therapeutics

A Triple Combination HIV Microbicide

Abstract: The HIV-positive population continues to rise despite a worldwide decline in the rates of infection caused by human immunodeficiency virus (HIV). The HIV virus continues to spread due to a lack of effective vaccines and pre-exposure prophylaxis methods, even though the availability and effectiveness of antiretroviral therapy has helped reduce...

Published: 4/8/2024 | Inventor(s): Barry O'Keefe, Paul Christou, Evangelia Vavamka, Theresa Capell

Keywords(s): Acquired Immunodeficiency Syndrome, ANTIBODY, ANTIVIRAL, HIV, Lectin, Microbicide, O’Keefe, Sexually Transmitted Diseases

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease