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Vaccine Attenuation via Deoptimization of Synonymous Codons

Research scientists at CDC have developed compositions and methods that can be used to develop attenuated vaccines having well-defined levels of replicative fitness and enhanced genetic stabilities. Infections by intracellular pathogens, such as viruses, bacteria, and parasites, are cleared in most cases after activation of specific T-cell immune responses...

Published: 7/25/2024 | Inventor(s): Cara Burns, Jacueline Quay, Jing Shaw, Olen Kew

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, CODONS, DC2XXX, DC4XXX, DC5XXX, DCXXXX, Deoptimization, DXXXXX, Fitness, Modulation, OID-NCIRD-DVD, Replicative, Synonymous, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WHXXXX, WIXXXX, WJXXXX, WMXXXX, XEXXXX, XHXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, ResearchProducts > Research Equipment, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Consumer Products, Application > Research Materials, Application > Therapeutics