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Novel Kinase Inhibitory Thiazines
Summary: The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including: Oncogenic gene fusion DNAJB1-PRKACA (PKADJ) Wild type protein kinase A (PKA) Protein kinase...
Published: 4/16/2026
|
Updated: 11/4/2024
|
Inventor(s):
Barry O'Keefe
,
Lin Du
,
Brice Wilson
,
Ping Zhang
,
William Moore
,
Dongdong Wang
,
Juliana Martinez Fiesco
,
Ning Li
Keywords(s):
Category(s):
Application
,
Application > Therapeutics
,
Collaboration Sought > Collaboration
,
TherapeuticArea > Oncology
,
TherapeuticArea > Infectious Disease
,
Collaboration Sought > Licensing
,
TherapeuticArea > Rare/Neglected Diseases
Reverse Thiazine Kinase Inhibitors
Summary: The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including: Oncogenic gene fusion DNAJB1-PRKACA (PKADJ) Wild type protein kinase A (PKA) Protein kinase...
Published: 4/16/2026
|
Updated: 10/30/2024
|
Inventor(s):
Barry O'Keefe
,
Lin Du
,
Brice Wilson
,
Ping Zhang
,
William Moore
,
Dongdong Wang
,
Juliana Martinez Fiesco
,
Ning Li
Keywords(s):
Category(s):
Application > Therapeutics
,
Collaboration Sought > Collaboration
,
TherapeuticArea > Oncology
,
TherapeuticArea > Infectious Disease
,
Collaboration Sought > Licensing
,
TherapeuticArea > Rare/Neglected Diseases
Novel Kinase Inhibitory Aplithianines
Summary: The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including: Oncogenic gene fusion DNAJB1-PRKACA (PKADJ) Wild type protein kinase A (PKA) Protein kinase...
Published: 4/16/2026
|
Updated: 10/29/2024
|
Inventor(s):
Barry O'Keefe
,
Lin Du
,
Brice Wilson
,
Ping Zhang
,
William Moore
,
Dongdong Wang
,
Juliana Martinez Fiesco
,
Ning Li
Keywords(s):
Category(s):
Application > Therapeutics
,
TherapeuticArea > Oncology
,
TherapeuticArea > Infectious Disease
,
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Rare/Neglected Diseases
Novel Human Insulin Cα-Peptide as an Antagonist for Islet and Brain Amyloidosis
Summary: The NIA seeks co-development partners and/or licensees for the further development of Cα-peptide as a therapeutic that inhibits islet amyloidosis. Description of Technology: Over 32 million Americans are living with Diabetes and newly diagnosed cases of type 1 and type 2 diabetes is increasing. A defining feature of type 2 diabetes...
Published: 4/24/2026
|
Updated: 8/2/2023
|
Inventor(s):
Qing Rong Liu
,
Min Zhu
,
Pingbo Zhang
,
Josephine Earley
,
Luigi Ferrucci
Keywords(s):
Alzheimer’s Disease
,
Amyloidosis
,
C-peptide
,
DIABETES
,
Egan
,
insulin
,
Islet Amyloid Polypeptide
,
Liu
,
National Institute on Aging
,
NIA
Category(s):
Collaboration Sought > Licensing
,
Collaboration Sought > Collaboration
,
Application > Therapeutics
,
TherapeuticArea > Endocrinology
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