Search Results - thyroid

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GTF2I Mutations as a Genetic Marker for Prognosis of Thymic Malignancies

Abstract: Thymoma and thymic carcinomas are a rare and poorly understood group of malignancies. Despite the growing number of biomarkers that are used for diagnosing and treating carcinomas in general, cancers of the thymus are still diagnosed, stratified and treated by a costly combination of histology, surgery and radiological procedures. The lack...

Published: 4/8/2024 | Inventor(s): Giuseppe Giaccone, Yisong Wang

Keywords(s): THYMIC, thymoma, THYROID

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics

Humanized Mouse Model to Study Mesothelin (MSLN) -targeted Cancer Therapeutics: Bl6/TPO Mice

Abstract: Mesothelin (MSLN) is an antigen highly expressed in several human cancers including mesotheliomas, ovarian cancers and pancreatic cancers. As such, human MSLN (hMSLN) is a target for many anti-cancer drugs. Most therapeutics targeting hMSLN do not recognize the mouse isoform of MSLN (mMSLN) and therefore cannot be tested in mouse cancer models. Investigators...

Published: 5/21/2024 | Inventor(s): Christine Alewine, Serguei Kozlov, Xianyu Zhang, Theresa Guerin, Theresa O'Sullivan, Norman Collins, Jerome Schlomer

Keywords(s): Alewine, Bl6/TPO, Cancer Animal Model, hMSLN, Humanized Mice, MESOTHELIN, MSLN, Murine Model, THYROID

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology