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FIBP Knockout Potentiates Therapeutic Effects of T-cell Based Therapies in Solid Tumors

Abstract: Despite recent breakthroughs in cancer immunotherapy, T-cell based therapies achieve limited efficacy in solid tumors. Immunosuppression, antigen escape and physical barriers to entry into solid tumors are issues faced. Identifying regulators in T-cell dysfunction remains challenging due to limitations of current screening platforms. Using...

Published: 12/17/2024 | Inventor(s): Peng Jiang, Yu Zhang

Keywords(s): adoptive cell therapy, Cancer Immunotherapy, cholesterol metabolism, Computational Model, FGF1 Intracellular Binding Protein, FIBP, Jiang, solid tumors, T-Cell based Therapy, T-Cell Resilience

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

Humanized Mouse Model to Study Mesothelin (MSLN) -targeted Cancer Therapeutics: Bl6/TPO Mice

Abstract: Mesothelin (MSLN) is an antigen highly expressed in several human cancers including mesotheliomas, ovarian cancers and pancreatic cancers. As such, human MSLN (hMSLN) is a target for many anti-cancer drugs. Most therapeutics targeting hMSLN do not recognize the mouse isoform of MSLN (mMSLN) and therefore cannot be tested in mouse cancer models. Investigators...

Published: 5/21/2024 | Inventor(s): Christine Alewine, Serguei Kozlov, Xianyu Zhang, Theresa Guerin, Theresa O'Sullivan, Norman Collins, Jerome Schlomer

Keywords(s): Alewine, Bl6/TPO, Cancer Animal Model, hMSLN, Humanized Mice, MESOTHELIN, MSLN, Murine Model, THYROID

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology