Search Results - varicella-zoster

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Safer Attenuated Virus Vaccines with Missing or Diminished Latency of Infection

This technology describes recombinant viruses that have weakened ability to establish and/or maintain latency and their use as live vaccines. The viruses have one or more genetic mutations that allow for continued replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the virus that causes...

Published: 7/25/2024 | Inventor(s): Lesley Pesnicak, Edward Cox, Jeffrey Cohen

Keywords(s): BUT, chickenpox, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Impaired, Latency, MUTANT, Patent Category - Biotechnology, REPLICATION, UAXXXX, Vaccine, VARICELLA-ZOSTER

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases, Application > Vaccines

A Varicella-Zoster Virus Mutant that is Markedly Impaired for Latent Infection Available for the Development of Shingles Vaccines and Diagnostics

Reactivation of latent Varicella-Zoster virus (VZV) infection is the cause of shingles, which is prominent in adults over the age of 60 and individuals who have compromised immune systems, due to HIV infection, cancer treatment and/or transplant. Shingles is a worldwide health concern that affects approximately 600,000 Americans each year. The incidence...

Published: 7/25/2024 | Inventor(s): Lesley Pesnicak, Jeffrey Cohen

Keywords(s): DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, imparied latency, Infection, Latent, MUTANT, ORF29 mutant, Varicella Zoster, VARICELLA-ZOSTER, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Vaccines