Search Results - replication

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Safer Attenuated Virus Vaccines with Missing or Diminished Latency of Infection

This technology describes recombinant viruses that have weakened ability to establish and/or maintain latency and their use as live vaccines. The viruses have one or more genetic mutations that allow for continued replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the virus that causes...

Published: 7/25/2024 | Inventor(s): Lesley Pesnicak, Edward Cox, Jeffrey Cohen

Keywords(s): BUT, chickenpox, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Impaired, Latency, MUTANT, Patent Category - Biotechnology, REPLICATION, UAXXXX, Vaccine, VARICELLA-ZOSTER

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases, Application > Vaccines

Method of Producing Immortalized Primary Human Keratinocytes for HPV Investigation, Testing of Therapeutics, and Skin Graft Generation

One of the major limitations of using cultured keratinocytes for research studies is that primary keratinocytes senesce after a few passages. Keratinocytes from specific anatomical sites are also difficult to culture. Scientists at the NIH have demonstrated that primary keratinocytes, from several anatomical sites, when treated with a small-molecule...

Published: 7/25/2024 | Inventor(s): Sandra Chapman, Jonathan Vogel, Atsushi Terunuma, Alison McBride

Keywords(s): AC4XXX, ACXXXX, AXXXXX, CC3XXX, CCXXXX, Complete, CXXXXX, DDXXXX, DXXXXX, EXTENDED, grafting, Human, IB2BXX, IB2XXX, IBXXXX, inhibitor, IXXXXX, KERATINOCYTES, Keratinocytes., Life-cycle, LONG-TERM, Maintenance, Papillomaviruses., Patent Category - Biotechnology, Persistence, Primary, PROLIFERATIVE, REPLICATION, ROCK, RXXXXX, SKIN, STATE, Studies., Sustain, Y-27632

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Therapeutics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Dermatology, TherapeuticArea > Infectious Disease