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Diagnostic and Therapeutic Use of Brother of the Regulator of Imprinted Sites (BORIS) Alternative Splice Forms

This technology identifies twenty five (25) new alternatively spliced transcripts of the BORIS gene. The transcripts lead to the expression of seventeen different protein isoforms with variable N- and C-termini encoded by BORIS gene locus. Differential expression levels of BORIS isoforms were observed in different cancers. While some BORIS alternative...

Published: 7/25/2024 | Inventor(s): Victor Lobanenkov

Keywords(s): Alternate, Boris, CA1AXX, CA1XXX, CANCER, CAXXXX, CB6XXX, CBXXXX, CXXXXX, Diagnostics, Forms, MULTIPLE, SPLICE, Tool, treatment

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Application > Therapeutics, Application > Diagnostics

Brother of the Regulator of Imprinted Sites (BORIS)

The subject application discloses an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding a human or a non-human BORIS, or a fragment of either of the foregoing; an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence that is complementary to a nucleotide sequence encoding...

Published: 7/25/2024 | Inventor(s): Victor Lobanenkov

Keywords(s): CA1AXX, CA1CXX, CAXXXX, CXXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics