Search Results - willaim+chain

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Natural product-based anti-cancer agents: aza-Englerin analogues

Abstract: Chemotherapy resistance in a wide array of cancers is often associated with enhanced glucose uptake and dysregulation of the insulin signaling pathway. Therapeutics capable of inhibiting insulin signaling would be valuable as a stand-alone treatment and for sensitizing resistant tumors to standard chemotherapy regiments. Researchers at NCI’s...

Published: 7/3/2024 | Inventor(s): Willaim Chain, John Beutler, William Figg, Joe Ramos, Florian Suizmaier, Zhenwu Li, Daniel Fash, Ian Talisman, Cody Peer

Keywords(s): Ewing, Glycolytic, insulin, Resistance, Sarcoma

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Tristetraprolin (TTP) Plasmid Vectors for Human and Mouse TTP

Tristetraprolin (TTP) is involved in the physiological regulation of the secretion of at least two important cytokines, tumor necrosis factor alpha (TNF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). TTP exerts its effects by directly binding to the mRNAs encoding these proteins and destabilizing them, resulting in less secretion. Conversely,...

Published: 7/25/2024 | Inventor(s): Wi Lai, Perry Blackshear

Keywords(s): Human, Listed LPM Wong as of 4/15/2015, Mouse, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Tristetraprolin, TTP, vectors

Category(s): Collaboration Sought > Licensing

TTP as a Regulator of GM-CSF mRNA Deadenylation and Stability

The disclosed invention provides materials and methods to treat granulocytopenia (low white cell count in the blood) which is characterized by a reduced number of granulocytes (relative) or an absence of granulocytes (absolute). This condition is commonly associated with cancer chemotherapy, but is seen less frequently in a number of conditions including...

Published: 7/25/2024 | Inventor(s): Wi Lai, Perry Blackshear, Ester Carballo

Keywords(s): Aplastic anemia, Deadenylation, Duke DNA Project, GM-CSF, Granulocytopenia, IB6XXX, IBXXXX, IXXXXX, REGULATOR, STABILITY, Systemic lupus erythematosus, TTP, UA1XXX

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Reproductive Health, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases

Regulation of RNA Stability

This invention relates to the discovery that tristetraprolin (TTP) can promote the poly(A)RNase (PARN) mediated deadenylation of polyadenylated substrates containing AU-rich elements (AREs). As one aspect of the invention, the inventors have developed a cell free system that may be used for the purposes of assessing the effects of the various system...

Published: 4/8/2024 | Inventor(s): Wi Lai

Keywords(s): GCXXXX, GXXXXX, IDXXXX, IXXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics