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Modified Peptide Nucleic Acids (PNAs) for Detection of DNA or RNA and Identification of a Disease or Pathogen
Case ID:
TAB-2535
Web Published:
12/6/2022
Description:
The NIH announces a novel method for fast, simple, and accurate detection of nucleic acids outside the modern laboratory. Nucleic acid testing is highly specific and often provides definitive identification of a disease or pathogen. Methods to detect nucleic acid sequences and identify a disease or pathogen are dominated by PCR, but applying PCR-based techniques in remote settings is challenging. Researchers at the NIH have developed a universal, colorimetric, nucleic acid-responsive diagnostic system that uses two short peptide nucleic acid (PNA) probes and does not rely on PCR. The design of a cyclopentane-modified surface probe and a biotin-containing reporter probe allows excellent DNA and RNA detection. NIH researchers have specifically demonstrated this technology's suitability for early detection of HIV RNA or anthrax DNA.
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Direct Link:
https://nih.technologypublisher.com/tech/Modified_Peptide_Nucleic_Acids_(PNAs )_for_Detection_of_DNA_or_RNA_and_Identification_of_a_Disease_or_Pathogen
Category(s):
Collaboration
Diagnostics
Infectious Disease
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For Information, Contact:
Betty Tong
Technology Licensing Specialist
NIH Technology Transfer
301-451-7836
tongb@niddk.nih.gov
Inventors:
Christopher Micklitsch
Bereket Yemane (formerly Oquare)
Chao Zhao
Daniel Appella
Keywords:
Acids
Cyclopentane-Peptide
DAXXXX
Detection
DXXXXX
Nucleic
Qualitative
QUANTITATIVE
YXXXXX
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