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RORgamma (RORC) Deficient Mice Which Are Useful for the Study of Lymph Node Organogenesis and Immune Responses
Case ID:
TAB-2041
Web Published:
12/6/2022
Description:
The retinoid-related orphan receptor gamma (RORgamma) is a member of the nuclear receptor superfamily. NIH investigators used homologous recombination in embryonic stem cells to generate mice in which the RORgamma gene was disrupted. RORgamma deficient mice lack peripheral and mesenteric lymph nodes and Peyer's patches indicating that ROR expression is indispensable for lymph node organogenesis. In addition, RORgamma is required for the generation of Th17 cells which play a critical role in autoimmune disease.
The RORgamma deficient mice are useful to identify the physiological functions of the RORgamma. RORgamma deficient mice also provide an excellent tool to study the role of RORgamma in immune responses and autoimmune disease, the study of the role of Th17 and interleukin 17 in these processes, and the analysis.
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Direct Link:
https://nih.technologypublisher.com/tech/RORgamma_(RORC)_Deficient_Mice_Which _Are_Useful_for_the_Study_of_Lymph_Node_Organogenesis_and_Immune_Responses
Category(s):
Collaboration
Licensing
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Therapeutics
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Diagnostics
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For Information, Contact:
Vidita Choudhry
Technology Development Specialist
NIH Technology Transfer
301-594-4095
vidita.choudhry@nih.gov
Inventors:
Anton Jetten
Keywords:
Autoimmune
DEFICIENT
Disease
IDXXXX
IMMUNE
IXXXXX
Mice
Responses
RORC
RORgamma
RXXXXX
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