Search Results - rorgamma

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An In-Vitro Cell System Useful For Identification of RORgamma Antagonists

The retinoid-related orphan receptors alpha, beta and gamma (RORalpha, beta and gamma , also referred to as NR1F1, 2 and 3, respectively) comprise a distinct subfamily of nuclear receptors. Study of ROR-deficient mice has implicated RORs in the regulation of a number of biological processes and revealed potential roles for these proteins in several...

Published: 7/25/2024 | Inventor(s): Yukimasa Takeda, Anton Jetten

Keywords(s): AC5XXX, ACXXXX, AXXXXX, Cell, Cells, CHO, Co-expressing, DEVELOPED, Expression, IDXXXX, IXXXXX, Reporter., RORC, RORE5-Luciferase, RORgamma, RXXXXX, System, TET-ON, Vector, Vitro

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Therapeutics

RORgamma (RORC) Deficient Mice Which Are Useful for the Study of Lymph Node Organogenesis and Immune Responses

The retinoid-related orphan receptor gamma (RORgamma) is a member of the nuclear receptor superfamily. NIH investigators used homologous recombination in embryonic stem cells to generate mice in which the RORgamma gene was disrupted. RORgamma deficient mice lack peripheral and mesenteric lymph nodes and Peyer's patches indicating that ROR expression...

Published: 7/25/2024 | Inventor(s): Anton Jetten

Keywords(s): Autoimmune, DEFICIENT, Disease, IDXXXX, IMMUNE, IXXXXX, Mice, Responses, RORC, RORgamma, RXXXXX, TOOLS

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Therapeutics, Application > Research Materials, Application > Diagnostics