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Wild-Type and DNA Polymerase beta Null Mouse Embryotic Fibroblast Cell Lines Harboring a lambda-LIZ Transgene
Case ID:
TAB-1077
Web Published:
12/6/2022
Description:
Of great utility in toxicology and DNA repair research are knockout mice with cell lines enabling one to evaluate generations of gene mutations as a direct function of base excision repair. Of particular importance are lambda-LIZ transgenes. Likewise, wild-type and beta-pol null cell lines are equally important. While there exist cell lines carrying the lambda-LIZ transgene, only wild-type cells are currently available. And while wild-type and beta-pol null cell lines exist, none carry the lambda-LIZ transgene.
The present cell line incorporates both of these beneficial properties. These cell lines were created by crossing a transgenic mouse with multiple copies of the lambda-LIZ transgene with a mouse with but a single copy of the DNA polymerase beta. Rebreeding offspring produced cells of both wild type and beta-pol null genotype. The utility of these cells stem from the deficiency in base excision repair as a result of the null mutation in the DNA polymerase beta gene.
Also available for licensing are cell lines created using:
Ung KO mice + lambda-LIZ transgene
Aag KO mice + lambda-LIZ transgene
PMS-2 KO mice + lambda-LIZ transgene
Pol-beta/Aag double KO mice + lambda-LIZ transgene
Pol-beta/PMS-2 double KO mice + lambda-LIZ transgene
Aag/PMS-2 double KO mice + lambda-LIZ transgene
Patent Information:
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App Type
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Patent No.
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Direct Link:
https://nih.technologypublisher.com/tech/Wild-Type_and_DNA_Polymerase_beta_Nu ll_Mouse_Embryotic_Fibroblast_Cell_Lines_Harboring_a_lambda-LIZ_Transgene
Category(s):
Licensing
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For Information, Contact:
Vidita Choudhry
Technology Development Specialist
NIH Technology Transfer
301-594-4095
vidita.choudhry@nih.gov
Inventors:
Robert Sobol
Keywords:
3-@hydroxyacyl-coa dehydrogenase deficiency
47 XYY syndrome
AC5XXX
ACXXXX
AXXXXX
B
Cell
DNA
Double Y
Embryonic
Fibroblast
HAD deficiency
harboring
HIS deficiency
Histidinemia
KO
Lines
Mouse
NULL
polymerase
SV40T-Ag
TRANSFORMED
TRANSGENE
WILD-TYPE
Y-LIZ
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