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4G10, a Monoclonal Antibody Against the Chemokine Receptor CXCR4, Raised Against a Synthetic Peptide of 38 Residues in Length Derived from the N-terminal Sequence of CXCR4
Case ID:
TAB-695
Web Published:
12/6/2022
Description:
This invention identifies a monoclonal antibody (4G10) against the chemokine receptor CXCR4 and is a mouse IgG1 antibody. CXCR4 has been identified as a co-receptor mediating entry of HIV-1 into T cells. Subsequently, CXCR4 has been implicated in normal physiological functions, including activation of B cells and B cell progenitors and guiding their migration into the bone marrow (via its ligand SDF-1). CXCR4 also functions in T cell progenitor migration and neural progenitor stem cell activation. Since 4G10 is a monoclonal antibody raised against a synthetic peptide derived from the N- terminus of CXCR4 that may prove useful in the context of the above CXCR4 functions, 4G10 is an excellent reagent for detection and quantitation of CXCR4 by Western blot, immunoprecipitation, ELISA, and flow cytometry. It can also be used to purify CXCR4 by affinity chromatography. With these known characteristics, it would also function in immuno-histochemical assays as well. Thus, this invention is a good research tool and is available for licensing through a Biological Materials License Agreement as no patent application has been filed.
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Direct Link:
https://nih.technologypublisher.com/tech?title=4G10%2c_a_Monoclonal_Antibody_ Against_the_Chemokine_Receptor_CXCR4%2c_Raised_Against_a_Synthetic_Peptide_o f_38_Residues_in_Length_Derived_from_the_N-terminal_Sequence_of_CXCR4
Category(s):
Licensing
Diagnostics
Research Materials
Infectious Disease
Therapeutics
Oncology
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For Information, Contact:
Benjamin Hurley
Office of Technology Transfer Center
NIH Technology Transfer
240-669-5092
benjamin.hurley@nih.gov
Inventors:
Edward Berger
Christopher Broder
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