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A Mouse Model of Multiple Endocrine Neoplasia, Type I
Case ID:
TAB-1281
Web Published:
12/6/2022
Description:
The current invention embodies a mouse model which is heterozygous for a null allele at the Men1 locus of murine chromosome 19. Men1 has similar exon-intron organization and amino acid identity compared with its human analog MEN1, which has been implicated in the pathogenesis of multiple endocrine neoplasia, type I (MENI). This mouse model has been shown to develop features remarkably similar to those of MEN1, which include tumors of the endocrine pancreas, pituitary, and parathyroids. The model embodied in this invention appears to represent a valuable research tool for use in elucidating the role of the wild-type Men1 allele in tumor formation, and ultimately should aid in the testing of possible therapeutic approaches to human MEN1.
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Direct Link:
https://nih.technologypublisher.com/tech?title=A_Mouse_Model_of_Multiple_Endo crine_Neoplasia%2c_Type_I
Category(s):
Licensing
Research Materials
Therapeutics
Oncology
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For Information, Contact:
Sangeetha Raghavan
Senior Licensing and Patenting Manager
NIH Technology Transfer
sangeetha.raghavan@nih.gov
Inventors:
Judy Crabtree
Francis Collins
Keywords:
CC1XXX
CC3XXX
CCXXXX
CXXXXX
endocrine
GB1A3X
GB1AXX
GB1XXX
GB2BXX
GB2XXX
GBXXXX
GCXXXX
GXXXXX
Men1 locus
Model
Mouse
mouse model
MULTIPLE
Multiple endocrine neoplasia
Multiple endocrine neoplasia type 1
Multiple endocrine neoplasia, type 2
murine chromosome 19
NEOPLASIA
tumor formation
TYPE
Zollinger-Ellison syndrome
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