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Dengue Tetravalent Vaccine Containing a Common 30 Nucleotide Deletion in the 3'-UTR of Dengue Types 1, 2, 3, and 4
Case ID:
TAB-671
Web Published:
12/6/2022
Description:
The invention relates to a dengue virus tetravalent vaccine containing a common 30-nucleotide deletion (delta30) in the 3'-untranslated region (UTR) of the genome of dengue virus serotypes 1, 2, 3, and 4. The previously identified delta30 attenuating mutation, created in dengue virus type 4 (DEN4) by the removal of 30 nucleotides from the 3'-UTR, is also capable of attenuating a wild-type strain of dengue virus type 1 (DEN1). Removal of 30 nucleotides from the DEN1 3'-UTR in a highly conserved region homologous to the DEN4 region encompassing the delta30 mutation yielded a recombinant virus attenuated in rhesus monkeys to a level similar to recombinant virus DEN4delta30. This established the transportability of the delta30 mutation and its attenuation phenotype to a dengue virus type other than DEN4. The effective transferability of the delta30 mutation establishes the usefulness of the delta30 mutation to attenuate and improve the safety of commercializable dengue virus vaccines of any serotype.
A tetravalent dengue virus vaccine containing dengue virus types 1, 2, 3, and 4 each attenuated by the delta30 mutation is being developed. The presence of the delta30 attenuating mutation in each virus component precludes the reversion to a wild-type virus by intertypic recombination. In addition, because of the inherent genetic stability of deletion mutations, the delta30 mutation represents an excellent alternative for use as a common mutation shared among each component of a tetravalent vaccine.
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Direct Link:
https://nih.technologypublisher.com/tech?title=Dengue_Tetravalent_Vaccine_Con taining_a_Common_30_Nucleotide_Deletion_in_the_3%27-UTR_of_Dengue_Types_1%2c _2%2c_3%2c_and_4
Category(s):
Licensing
Rare / Neglected Diseases
Diagnostics
Infectious Disease
Therapeutics
Vaccines
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For Information, Contact:
Peter Soukas
Technology Licensing Specialist/TTPS
NIH Technology Transfer
301-496-2644
peter.soukas@nih.gov
Inventors:
Brian Murphy
Lewis Markoff
Barry Falgout
Kathryn Hanley
Joseph Blaney
Stephen Whitehead
Keywords:
3'-UTR
ANTIGENIC
chimeric
Chromosome 7, monosomy
DA4BXX
DA4XXX
DAXXXX
DB4BXX
DB4XXX
DBXXXX
DC5BXX
DC5XXX
DCXXXX
Deletion
Deletion 7
DENGUE
Dengue (Flaviviridae)
DXXXXX
Nucleotide
Tetravalent
UAXXXX
UBXXXX
Vaccine
Viruses
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