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Hybridoma C4H3, Monoclonal Antibody to a Specific Peptide-MHC Class II Complex
Case ID:
TAB-1685
Web Published:
12/6/2022
Description:
T lymphocytes play an important role in the immune system by recognizing foreign protein motifs on cells. T lymphocytes are stimulated to recognize these motifs through their interactions with peptide-MHC complexes (pMHC). Thus, studying pMHC is an important aspect of understanding how the immune system works, particularly with regard to the development of vaccines. Unfortunately, the detection of pMHC is largely dependent on indirect assays, due to the difficulty of producing antibodies for specific pMHC.
This invention regards the development of hybridomas (C4H3) for the production of antibodies that are highly specific for a particular pMHC complex consisting of hen egg lysozyme peptide 46-61 (HEL) and the I-A
k
MHC class II molecule. These antibodies can be used for a myriad of purposes which include studying how cells form pMHC.
Patent Information:
Title
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Serial No.
Patent No.
File Date
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Direct Link:
https://nih.technologypublisher.com/tech?title=Hybridoma_C4H3%2c_Monoclonal_A ntibody_to_a_Specific_Peptide-MHC_Class_II_Complex
Category(s):
Collaboration
Immunology
Oncology
Research Materials
Diagnostics
Antibodies
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For Information, Contact:
Daniel Lee
TTPS/Technology Transfer Manager
NIH Technology Transfer
301-761-6327
daniel.lee5@nih.gov
Inventors:
Ronald Germain
Keywords:
ANTIBODY
CA1BXX
CA1XXX
CA2AXX
CA2XXX
CAXXXX
Class
COMPLEX
CXXXXX
Hybridoma
Mab
monoclonal
Peptide-MHC
RM
Specific
WIXXXX
XAXXXX
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