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Rabbit Polyclonal Antibody to Detect a Pro-peptide Fragment of NSAID-activated Gene (NAG-1)/GDF15, a Protein Associated with Cancer
Case ID:
TAB-2442
Web Published:
12/6/2022
Description:
Chronic inflammation is clearly associated with an increase in the risk of cancer. Non-steroidal anti-inflammatory drugs (NSAIDs) are well documented as agents that inhibit tumor growth and with long-term use can prevent tumor development. NSAID-activated gene (NAG-1), a unique member of the TGF-beta superfamily, is highly induced by NSAIDs and numerous drugs and chemicals with anti-tumorigenic activities.
The protein product of NAG-1 is first formed into an immature peptide dimer that must be cut at a specific site before it can be secreted as a mature protein. Currently available antibodies can only detect either the immature form of NAG-1 or the secreted mature protein, but do not recognize the peptide fragment that remains when the immature dimer is cut to form the mature protein. Now available for the first time, the present new antibody recognizes this NAG-1 pro-peptide fragment.
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Direct Link:
https://nih.technologypublisher.com/tech?title=Rabbit_Polyclonal_Antibody_to_ Detect_a_Pro-peptide_Fragment_of_NSAID-activated_Gene_(NAG-1)%2fGDF15%2c_a_P rotein_Associated_with_Cancer
Category(s):
Collaboration
Research Materials
Oncology
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For Information, Contact:
Vidita Choudhry
Technology Development Specialist
NIH Technology Transfer
301-594-4095
vidita.choudhry@nih.gov
Inventors:
Thomas Eling
Keywords:
ANTIBODY
CC3AXX
CC3XXX
CCXXXX
CXXXXX
Detection
NAG-1/Gdf15
polyclonal
Pro-peptide
rabbit
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