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Swine Hepatitis E Virus Available For Use in Diagnosis, Prevention and Treatment of Hepatitis E
Case ID:
TAB-1455
Web Published:
12/6/2022
Description:
Hepatitis E virus (HEV) is the cause of Hepatitis E, a liver disease that occurs primarily in developing countries due to fecal contaminated drinking water. Outbreaks of HEV infection have caused epidemics in Africa, Central and Southeast Asia and Mexico and cases of the disease have also been reported sporadically in more developed countries. Hepatitis E is most often overcome by a host’s natural defenses; however the disease is more severe in pregnant women, who exhibit a 20% mortality rate due to HEV infection. Presently, no vaccines or therapeutic agents, which prevent or treat HEV infection, are commercially provided.
An isolated strain of swine HEV is currently available for licensing and commercial development. The nucleotide and amino acid sequences of the available virus are significantly homologous to human HEV and antibodies induced by the agent were shown to cross react with a human HEV antigen. The present technology provides a mechanism for augmenting the immune response against HEV in infected individuals and is thus useful for the development of novel vaccines and therapeutics for prevention and treatment of HEV infection in humans. In addition, the available viral strain may be used to develop diagnostic tools for efficient detection of HEV contamination of food and water in developing countries, especially in regions of Africa, Asia and Mexico, where HEV is endemic.
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Direct Link:
https://nih.technologypublisher.com/tech?title=Swine_Hepatitis_E_Virus_Availa ble_For_Use_in_Diagnosis%2c_Prevention_and_Treatment_of_Hepatitis_E
Category(s):
Collaboration
Licensing
Rare / Neglected Diseases
Infectious Disease
Vaccines
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For Information, Contact:
Peter Soukas
Technology Licensing Specialist/TTPS
NIH Technology Transfer
301-496-2644
peter.soukas@nih.gov
Inventors:
Suzanne Emerson
Robert Purcell
Xiang-jin Meng
Keywords:
DC5BXX
DC5XXX
DCXXXX
Duke DNA Project
DXXXXX
e
Hepatitis
Hepatitis A
Hepatitis D
Hepatitis E
HEV
PCT/US98/14665
Swine
THEREOF
UAXXXX
USES
virus
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