Search Results - ResearchProducts+%3e+Human+iPSC+Lines

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Transgene Free Non-human Primate Induced Pluripotent Stem Cells (iPSCs) for Use in Pre-clinical Regenerative Medicine Research

This technology includes rhesus macaque induced pluripotent stem cells (iPSCs) lines from multiple animals and various types of cells to establish this pre-clinical model. iPSCs are a type of pluripotent stem cell that can be generated from adult somatic cells. The iPSC technology holds great potential for regenerative medicine. Before clinical application,...

Published: 8/12/2024 | Inventor(s): Cynthia Dunbar, So Gun Hong, Thomas Winkler

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Animal Models, ResearchProducts > Human iPSC Lines

A Highly Efficient Differentiation Protocol for Placental Cells Derived from Human Pluripotent Stem Cells for Diagnostic and Therapeutic Applications

This technology includes in vitro-generated trophectoderm (TE) cells, which are ideal for modeling diseases of the placenta, drug screening, and cell-based therapies. The TE lineage which gives rise to placental cells during early human development. Derivation of definitive placental cells from human pluripotent stem cells in culture remains controversial...

Published: 8/12/2024 | Inventor(s): William Havel, Jeremy Newkirk, Rita Hadley, Yun Zhou

Keywords(s):

Category(s): Application > Diagnostics, Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Human Cell Lines, ResearchProducts > Human iPSC Lines

Generation of Safe-harbor Gene Targeting Donor Plasmids

This technology includes two safe harbor gene targeting donors, specifically designed for applications in the study of induced pluripotent stem cells (iPSC). These include the pAAVS1D-CMV.RFP-EF1a.copGFPpuro and pAAVS1-iCLHN donors. A key feature of these donors is their ability to integrate various transgenes into specific loci through homologous recombination,...

Published: 9/10/2024 | Inventor(s): Jizhong Zou, Mahendra Rao

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Materials Available, ResearchProducts > Human iPSC Lines, ResearchProducts > Plasmids/Vectors

Generation of Gene Specific Targeting Donor Plasmid (p5KI-GP-CHN and p3KI-GP-CHN)

This technology includes the use of engineered human induced pluripotent stem cells (iPSCs) for various applications such as studying cell differentiation, drug screening, and gene transfer therapy. It employs gene targeting donors flanked by DNA sequences compatible with endogenous loci to integrate transgenes through homologous recombination. A key...

Published: 9/10/2024 | Inventor(s): Jizhong Zou, Mahendra Rao

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Human iPSC Lines, TherapeuticArea > Neurology

Neuronal Differentiation of Neural Stem Cells with StemPro Embryonic Stem Cell Serum Free Medium for Research and Therapeutic Development

This technology involves an innovative method for differentiating neural stem cells (NSCs) into neurons, primarily for use in basic science research and in developing therapies for brain and spinal cord disorders. Existing methods for generating neurons from NSCs typically result in high efficiency but low survival rates, especially when neurons are...

Published: 8/12/2024 | Inventor(s): Nasir Malik, Mahendra Rao

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Human iPSC Lines, TherapeuticArea > Neurology

Three Cell Lines of Motor Neuron Progenitors for Various Diagnostic and Therapeutic Uses

This technology includes three distinct cell lines of motor neuron progenitors, derived from different sources: human induced pluripotent stem cell (iPSC) line BC1, human iPSC line X1, and human embryonic stem cell (hESC) line H14. These cell lines hold significant potential for multiple diagnostic and therapeutic applications. A key advantage of these...

Published: 8/12/2024 | Inventor(s): Mahendra Rao

Keywords(s):

Category(s): Application > Diagnostics, Collaboration Sought > Materials Available, ResearchProducts > Human iPSC Lines, Application > Therapeutics

Cell Lines of Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cell (iPSC) lines for Multiple Neurological Therapeutic and Diagnostic Uses

This technology includes three cell lines of dopaminergic neurons derived from human induced pluripotent stem cell (iPSC) line BC1, human iPSG line X1 and human embryonic stem cell (hESC) line H14 to be utilized in neurology research. These cell lines will be used for to study the biology of brain development and may also be used to test different characterization...

Published: 8/12/2024 | Inventor(s): Mahendra Rao

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Human iPSC Lines, TherapeuticArea > Neurology

Engineered Human Induced Pluripotent Stell Cell (iPSC) Lines for Multiple Therapeutic and Diagnostic Uses

This technology includes ten engineered human induced pluripotent stem cell (iPSC) lines with reported genes inserted into safe harbor sites for use in therapy and diagnostic screening assay development as well as basic stem cell biology research. These cell lines have the potential to differentiate into all cells in the body, and theoretically can...

Published: 9/10/2024 | Inventor(s): Mahendra Rao

Keywords(s):

Category(s): Application > Diagnostics, Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Human iPSC Lines

Method To Generate Chondrocytes from Human Induced Pluripotent Stem Cells (hIPSCs) and their use in Repairing Human Injury and Degenerative Diseases

This technology includes a method for differentiating human induced pluripotent stem cells (hiPSCs) into stable chondrocytes, capable of producing cartilage, and their use in cartilage repair in human injury and degenerative diseases. In suspension culture, hiPSC aggregates demonstrate gene and protein expression patterns similar to articular cartilage....

Published: 8/12/2024 | Inventor(s): Pamela Robey, Stephen Gadomski

Keywords(s):

Category(s): Application, Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Human iPSC Lines, ResearchProducts > Human Cell Lines, TherapeuticArea > Immunology