Search Results - TherapeuticArea+%3e+Infectious+Disease

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Single Source-Detector Separation Approach to Calculate Tissue Oxygen Saturation

Summary: The National Institute of Child Health and Human Development (NICHD) seeks partners and/or licensees to further develop and commercialize the miniaturized tissue oximeter for implementing the single source-detector separation algorithm in existing devices/systems to collect tissue oxygen saturation. Description of Technology: Tissue oxygen...

Published: 9/18/2024 | Inventor(s): Thien Nguyen, Amir Gandjbakhche, Soongho Park, Brian Hill

Keywords(s):

Category(s): Application > Medical Devices, Collaboration Sought > Collaboration, TherapeuticArea > Respiratory, TherapeuticArea > Neurology, TherapeuticArea > Infectious Disease

Prazoles as Potential Broad Spectrum Anti-viral Agents

The technology described involves the use of a compound called prazole as an anti-viral agent specifically targeting HIV-1. It was found that prazole binds to a protein called Tsg101, which is crucial for the virus's life cycle. This binding disrupts the normal interaction of Tsg101 with another protein, ubiquitin, thereby inhibiting the release...

Published: 8/12/2024 | Inventor(s): Carol Carter, Lorna Ehrlich

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease

Epstein-Barr Virus (EBV)-feeder Cell Line

This technology includes irradiated Epstein-Barr virus-transformed lymphoblastoid cell lines (EBV-LCL) as feeder cells for the ex vivo expansion of natural killer (NK) cells. EBV-LCL feeder cells, altered by radiation to prevent uncontrolled growth, provide a supportive environment for NK cells to multiply effectively. This method addresses the challenge...

Published: 8/12/2024 | Inventor(s): Richard Childs

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Human Cell Lines, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology

SARS-CoV-2 Neutralizing Nanobodies for Therapeutic and Diagnostic Uses

This technology involves the utilization of highly effective nanobodies, specifically camelid antibodies, derived from immunized llamas to neutralize SARS-CoV-2. Additionally, it employs a unique mouse model, called a "nanomouse," that is engineered to express antibody genes from camels, alpacas, and dromedaries. These nanobodies offer significant...

Published: 7/30/2024 | Inventor(s): Rafael Casellas, Jianliang Xu

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Materials Available, ResearchProducts > Animal Models, TherapeuticArea > Infectious Disease

Intranasal or Inhaled Delivery of a Custom IgA Antibody for Protection Against COVID-19

This technology includes an IgA antibody, specifically designed to target the receptor binding domain of SARS-CoV-2, the virus causing COVID-19. Administered intranasally, this antibody has potential neutralizing activity, aiming to prevent COVID-19. IgA, an antibody class present in mucosal areas, plays a crucial role in immune defense at the initial...

Published: 8/12/2024 | Inventor(s): Kaitlyn Sadtler, Mathew Memoli

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Infectious Disease

TSLP Induces Neutrophil-mediated Killing of Methicillin-resistant Staphylococcus Aureus (MRSA)

This technology includes the use of thymic stromal lymphopoetin (TSLP) for the treatment of MRSA. Our studies show that mouse neutrophils express the TSLP receptor, TSLPR, and that TSLP protein is increased during cutaneous MRSA infection. Using in vitro MRSA whole blood killing assays, we show that TSLP acts on mouse neutrophils to enhance MRSA killing....

Published: 8/12/2024 | Inventor(s):

Keywords(s):

Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Research Materials

Identification of a Novel Parvovirus for Vaccine Development and Use as a Diagnostic Tool

This technology includes a procedure for novel virus identification in a variety of human specimens by solexa high-throughput sequencing, which allows for the screening a large number of clinical specimens for novel virus discovery in a highly efficient and relatively economical method. By using this technique, we have successfully identified a novel...

Published: 9/5/2024 | Inventor(s): Ning Zhi, Neal Young, Baoyan Xu, Keji Zhao, Gangqing Hu

Keywords(s):

Category(s): Application > Diagnostics, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease

Photoactivatable Lipid-based Nanoparticles as a Vehicle for Dual Agent Delivery

Abstract: The invention relates to novel lipid-based nanoparticles (liposomes) for use in targeted, on demand and on site drug delivery. The particles include a wall surrounding a cavity, wherein the wall is comprised of: A lipid bilayer comprising 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC), dipalmitoylphosphatidylcholine...

Published: 4/8/2024 | Inventor(s): Anu Puri, Robert Blumenthal, Amit Joshi, Darayash Tata, Mathias Viard

Keywords(s): Combination Therapy, Delivery Agent, Infections (bacteria and viruses), Lipid nanoparticle, liposome, On-demand Drug Release, photoactivation, therapeutic delivery

Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Dermatology, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Collaboration Sought > Licensing, TherapeuticArea > Cardiology

A Sensitive, High Throughput Pseudovirus-Based Papillomavirus Neutralization Assay for HPV 16 and HPV 18

Abstract: Human Papilloma Viruses (HPV) is a very common virus; nearly 80 million people—about one in four—are currently infected in the United States. HPV is a group of more than 150 related viruses. Each HPV virus in this large group is given a number which is called its HPV type. HPV is named for the warts (papillomas) some that HPV types can cause....

Published: 4/8/2024 | Inventor(s): John Schiller, Christopher Buck, Diana Pastrana, Douglas Lowy, Richard Roden

Keywords(s): assay, bovine papillomavirus, HPV, Human Papilloma Viruses

Category(s): TherapeuticArea > Infectious Disease, Application > Research Materials, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Topoisomerase III (TOP3) Inhibitors as Antiviral and Anticancer Compounds based on Bisacridines

Abstract: Topoisomerase 3B (TOP3B) is the only topoisomerase that can act on RNA as well as DNA. Thus, it is a target of interest for the development of cancer therapies and RNA viral infection therapies. TOP3B is not an essential gene for carcinogenesis, but a subset of cancer cells with pre-existing genome instability are particularly vulnerable to...

Published: 4/8/2024 | Inventor(s): Yves Pommier, Sourav Saha, Wenjie Wang, Shar-yin Huang

Keywords(s): Bisacridines, CANCER, Pommier, SARS-CoV-2, TOP, TOP3, TOP3 Inhibitor, TOPOISOMERASE, Topoisomerase III, Topoisomerase Inhibitor, viral infection

Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

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