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Construct for Tetracycline Inducible Podocyte Specific Gene Expression in Mice

The National Institutes of Health announces the generation of a construct by ligating 2.5kb human podocin promoter sequence to gene encoding reverse tetracycline-controlled transcriptional activator which enables tetracycline-inducible podocyte specific gene of interest expression with another construct consisting of tetracycline responsive element,...

Published: 7/25/2024 | Inventor(s): Jeffrey Kopp

Keywords(s): CONSTRUCT, Expression, Gene, IDXXXX, INDUCIBLE, IXXXXX, Mice, Podocyte, Specific, Tetracycline

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics

Conditionally Immortalized Human Podocyte Cell Lines

Podocytes, cells of the visceral epithelium in the kidneys, are a key component of the glomerular filtration barrier. Podocyte damage and loss contribute to the initiation of glomerular diseases. NIH investigators recently established long-term urinary cell cultures from two patients with focal segmental glomerulosclerosis and two healthy volunteers,...

Published: 7/25/2024 | Inventor(s): Toru Sakairi, Jeffrey Kopp

Keywords(s): Cell, Conditionally, ESTABLISHED, Human, IDXXXX, immortalized, IXXXXX, Lines, Podocyte, RXXXXX, Urine

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics