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Simple, Rapid, and Sensitive Real-Time PCR Assays for Detecting Drug Resistance of HIV
Case ID:
TAB-2750
Web Published:
12/6/2022
Description:
This novel assay features real-time PCR reagents and methods for detecting drug-resistance related mutations in HIV, for newly diagnosed patients and those individuals currently receiving antiretroviral therapies. As the use of antiretroviral compounds to treat HIV infection proliferates, viruses adapt and evolve mutations limiting the efficacy of these drugs and disrupting the success of treatment. To address this problem, CDC researchers have developed this RT-PCR assay, intended for diagnosis of different point mutations in patient samples at an achievable sensitivity of 1-2 log greater than conventional point-mutation sequencing methods. More specifically, this assay measures the differential amplifications of common and mutation-specific reactions that target specific codons of interest. Given its low cost, simplicity, high-throughput capability, and tremendous diagnostic sensitivity, this assay will be useful for detection and surveillance of drug resistance-associated mutations and will aid in the clinical management of HIV infection.
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Direct Link:
https://nih.technologypublisher.com/tech?title=Simple%2c_Rapid%2c_and_Sensiti ve_Real-Time_PCR_Assays_for_Detecting_Drug_Resistance_of_HIV
Category(s):
Licensing
Software / Apps
Dental
Ophthalmology
Endocrinology
Occupational Safety and Health
Therapeutics
Diagnostics
Oncology
Research Materials
Computational models/software
Consumer Products
Cardiology
Infectious Disease
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For Information, Contact:
Jeremiah Mitzelfelt
NIH Technology Transfer
301-443-8518
jeremiah.mitzelfelt@nih.gov
Inventors:
Jonathan Lipscomb
Walid Heneine
Jeffrey Johnson
Keywords:
1
ANTIVIRAL
Anti-Viral
ASSAYS
CDC Docket Import
CDC Docket Import CDC Prosecuting
DA4XXX
DAXXXX
DETECTING
DRUGS
DXXXXX
HIV
HIV-1
Listed LPM Houze as of 4/15/2015
MUTATION
NCHHSTP-DHPSE
OID-NCHHSTP-DHPSE
PCR
POINT
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
REAL-TIME
Resistance
VLXXXX
VPXXXX
WBXXXX
WFXXXX
XBXXXX
XCXXXX
XEXXXX
YBXXXX
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