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Transgenic Mice with Conditionally-Enhanced Bone Morphogen Protein (BMP) Signaling: A Model for Human Bone Diseases
Case ID:
TAB-1831
Web Published:
12/6/2022
Description:
This technology relates to novel animal models of several human bone diseases that have been linked to enhanced BMP signaling. More specifically, this mouse model expresses a mutant receptor for BMP, known as Alk2 that is always actively signaling. This receptor is under the control of the Cre-loxP system, which allows control of expression of the mutant Alk2 in both a developmental and tissue-specific manner. As a result, the enhanced signaling conditions exhibited in multiple human bone-related diseases can be studied with the same animals.
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Direct Link:
https://nih.technologypublisher.com/tech?title=Transgenic_Mice_with_Condition ally-Enhanced_Bone_Morphogen_Protein_(BMP)_Signaling%3a__A_Model_for_Human_B one_Diseases
Category(s):
Licensing
Therapeutics
Animal Models
Diagnostics
Research Materials
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For Information, Contact:
Vidita Choudhry
Technology Development Specialist
NIH Technology Transfer
301-594-4095
vidita.choudhry@nih.gov
Inventors:
Manas Ray
Gregory Scott
Yuji Mishina
Keywords:
BAXXXX
BMP:
Bone
Craniosynostosis
Disease
Enhanced
Expressing
Fibrodysplasia ossificans progressiva
Human
IDXXXX
IXXXXX
Model
MORPHOGENETIC
Mouse
MULTIPLE MYELOMA
Protein
SIGNALING
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