Search Results - Application+%3e+Vaccines

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Immunogens, Compositions, and Methods for the Treatment of Dyslipidemia

This technology includes a novel vaccine for forming autoantibodies against apoC-III, a plasma enzyme that inhibits lipolysis. The vaccine can possibly be used to treat patients with high triglycerides and are at risk for pancreatitis and cardiovascular disease. This disclosure describes an ApoC3 immunogen that includes an antigenicApoC3 peptide linked...

Published: 8/12/2024 | Inventor(s): Alan Remaley

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Application > Vaccines, Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Metabolic Disease

Compositions and Methods for Reducing Serum Triglycerides

This technology includes a vaccine for lowering plasma triglycerides by inducing the formation of autoantibodies against either ANGPTL3 or ANGPTL4, which are inhibitors of Lipoprotein Lipase. This was done by conjugating synthetic peptides based on ANGPTL3 or ANGPTL4 to virus- like particles (VLPS). Injection of the vaccine in animal models was shown...

Published: 9/11/2024 | Inventor(s): Alexandra Fowler, Alan Remaley, Marcelo Amar, Bryce Chackerian

Keywords(s):

Category(s): Application > Therapeutics, Application > Research Materials, Application > Vaccines, Collaboration Sought > Licensing, TherapeuticArea > Cardiology

Alpha-galactosidase-A Knockout Mouse Model for Studying Fabry Disease

This technology includes an alpha-galactosidase-A knockout mouse model that can be used to study Fabry disease, an X-linked lysosomal storage disorder. Alpha-galactosidase-A is a crucial enzyme responsible for the breakdown of glycolipids, particularly globotriaosylceramide (Gb3), within lysosomes. In Fabry disease, a rare and inherited lysosomal storage...

Published: 4/8/2024 | Inventor(s): Toshio Ohshima, Ashok Kulkarni, Roscoe Brady, Gary Murray

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Application > Vaccines, Collaboration Sought > Materials Available, ResearchProducts > Animal Models, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Metabolic Disease

High Efficacy Vaccine and Microbicide Combination For Use Against HIV

Abstract: Human immunodeficiency virus (HIV) remains a major global health challenge despite the advancement made in development of effective antiretrovirals (ARVs). ARVs are effective at limiting replication and spread of the virus, and progression to acquired immuno-deficiency syndrome (AIDS). However, ARVs often lead to emergence of drug-resistant...

Published: 8/5/2024 | Inventor(s): Genoveffa Franchini, Marjorie Robert-Guroff, Daniel Appella, Sabrina Helmold Hait, Mohammed Rahman, Massimiliano Bissa, Ettore Appella, Lisa Marie Jenkins, Isabela Silva De Castro

Keywords(s): Acquired Immuno-Deficiency Syndrome, ADCC, AIDS, Antibody-dependent Cellular Cytotoxicity, Efferocytosis, Envelope Glycoprotein 120, Envelope Variable Region, Franchini, gp120, HIV, Human Immunodeficiency Virus, Microbicide, SAMT-247, V1, Vaccine

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, Application > Vaccines

Adjuvanted Mucosal Subunit Vaccines for Preventing SARS-CoV-2 Transmission and Infection

Abstract: The Corona virus disease, 2019 (COVID-19) pandemic is a worldwide public health crisis with over 153 million confirmed cases and 3.2 million deaths as of April 2021. COVID-19 is caused by a novel coronavirus called SARS-CoV-2. SARS-COV-2 infects hosts via its spike (S) protein, which has two portions, S1 that binds the cell and S2 that is...

Published: 8/14/2024 | Inventor(s): Jay Berzofsky, Yongjun Sui

Keywords(s):

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease

Vaccines for HIV

Abstract: The development of an effective HIV vaccine has been an ongoing area of research. The high variability in HIV-1 virus strains has represented a major challenge in successful development. Ideally, an effective candidate vaccine would provide protection against the majority of clades of HIV. Two major hurdles to overcome are immunodominance...

Published: 5/22/2024 | Inventor(s): Barbara Felber, George Pavlakis, Antonio Valentin, James Mullins

Keywords(s): ENV, GAG, HIV Vaccine, immunogenic conserved elements

Category(s): Collaboration Sought > Collaboration, Application > Vaccines, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease

A Dendritic Cell Vaccine to Immunize Cancer Patients Against Mutated Neoantigens Expressed by the Autologous Cancer

Abstract: Vaccines against non-viral cancers target mainly differentiation antigens, cancer testis antigens, and overexpressed antigens. One common feature to these antigens is their presence in central immunological tolerance. Using these vaccines, T cells underwent depletion of high avidity clones directed against such antigens. This depletion can...

Published: 4/8/2024 | Inventor(s): Gal Cafri, Paul Robbins, Jared Gartner, Steven Rosenberg

Keywords(s): CANCER, Dendritic cells, Immunotherapy, Neoantigens, Rosenberg, T Cells, vaccines

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Vaccines

Bacteriophage Based-Vaccine System

Abstract: Vaccines have become one of the most important tools in the fight against cancers and infectious diseases. However, some vaccines have shown limitations due to their high cost and low immune responses. To overcome these limitations, bacteriophages were proposed for the development of more cost-effective, immunogenic vaccines. Phages have shown...

Published: 4/8/2024 | Inventor(s): Sankar Adhya, Donald Court, Xintian Li, Manoj Rajaure

Keywords(s): Adhya, Bacteriophage Engineering, Bacteriophage Genetics, CANCER VACCINE, Infectious Diseases, Lambda Vector, Phage Therapy, Recombineering, Vaccine

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Vaccines

Novel Regulatory B cells for Treatment of Cancer and Autoimmune Disease

Abstract: The manner by which cancers evade the immune response is not well-understood. What is known is that the manner is an active process that regulates immune responses employing at least two types of suppressive cells, myeloid-derived suppressive cells and regulatory T cells (Tregs), a key subset of CD4+ T cells that controls peripheral tolerance...

Published: 8/14/2024 | Inventor(s): Bira Arya, Purevdorj Olkhanud, Ioana Bodogai

Keywords(s): IMMUNOTHERAPEUTIC, Immunotherapy, suppressive regulatory B cells, tBregs

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Vaccines

Brachyury-directed Vaccine for the Prevention or Treatment of Cancers

Abstract: Tumor invasion and metastasis are the primary drivers of cancer-related mortality. Therapies that have an ability to specifically target invasive and/or metastatic cells are anticipated to have a significant impact in the clinical management of advanced cancers. Researchers at the NCI have developed a vaccine technology that stimulates the...

Published: 4/8/2024 | Inventor(s): Jeffrey Schlom, Claudia Palena

Keywords(s): Brachyury, CANCER VACCINE, Immunotherapy, T-CELLS, Transcription factor

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Application > Vaccines, Collaboration Sought > Licensing

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