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C
o
mpositions and Methods for Producing Dendritic Cell-based Vaccines with Enhanced Efficacy
Summary: The Nati
o
nal Cancer Institute (NCI) is seeking research co-development partners and/or licensees for NCI’s compositions and methods to enhance the efficacy of dendritic cell (DC)-based cancer vaccines. Description of Technology: Current dendritic cell (DC)-based cancer vaccines are limited by impaired DC function due to cancer-driven...
Published: 7/15/2025
|
Inventor(s):
Jay Berz
o
fsky
,
Shweta Tiwary
Keywords(s):
Category(s):
TherapeuticArea >
O
ncology
,
TherapeuticArea > Immun
o
logy
,
Applicati
o
n > Therapeutics
,
C
o
llaboration Sought > Collaboration
,
C
o
llaboration Sought > Licensing
Enhanced Tum
o
r Reactivity of T Cells Lacking SIT1, LAX1 or TRAT1
Summary: The Eunice Kennedy Shriver Nati
o
nal Institute of Child Health and Human Development (NICHD) is actively seeking potential licensees interested in further developing these inhibitory transmembrane adapter proteins as targets for T-cell immunotherapy for the treatment of cancer, infectious diseases, and autoimmune diseases. Description of Technology: Cellular...
Published: 7/14/2025
|
Inventor(s):
Paul L
o
ve
,
Avik Dutta
Keywords(s):
Category(s):
Applicati
o
n > Therapeutics
,
TherapeuticArea >
O
ncology
,
TherapeuticArea > Immun
o
logy
Anti-Nucle
o
protein Crimean-Congo Hemorrhagic Fever Virus Monoclonal Antibodies for Assay Creation
Crimean-C
o
ngo hemorrhagic fever (CCHF) is the most widespread form of viral hemorrhagic fever, found in Eastern and Southern Europe, the Mediterranean, northwestern China, central Asia, Africa, the Middle East, and the Indian subcontinent. Typically beginning with non-specific fever, myalgia, nausea, diarrhea, and general malaise, symptoms of infection...
Published: 7/3/2025
|
Inventor(s):
Daniel D
o
uek
,
David Hawman
,
Le
o
nid Serebryannyy
,
N
o
emia Santana Lima
,
Chaim Schramm
,
Sarah Smith (Kerscher)
,
Amy Henry
,
Alicen Spaulding
Keywords(s):
Category(s):
Applicati
o
n
,
Applicati
o
n > Diagnostics
,
C
o
llaboration Sought
,
C
o
llaboration Sought > Licensing
,
C
o
llaboration Sought > Materials Available
,
ResearchPr
o
ducts > Antibodies
,
TherapeuticArea
,
TherapeuticArea > Infecti
o
us Disease
,
TherapeuticArea > Immun
o
logy
,
TherapeuticArea > Rare/Neglected Diseases
Vascularized Thyr
o
id-on-a-Chip for Personalized Drug Screening and Disease Modeling
This techn
o
logy includes a micro-engineered “thyroid-on-a-chip” that combines human thyroid organoids with integrated micro-vasculature to replicate the gland’s native blood flow and 3-D architecture, enabling rapid, patient-specific drug screening. By permitting real-time perfusion of nutrients, hormones, and immune cells, the platform...
Published: 7/15/2025
|
Inventor(s):
Anagha Rama Varma
,
Parnika Kant
,
Kaitlyn Sadtler
,
Parinaz Fathi
,
Nic
o
le Morgan
,
Paniz Rezvan Sangsari
,
Madis
o
n Daminato
Keywords(s):
Category(s):
Applicati
o
n > Diagnostics
,
Applicati
o
n > Medical Devices
,
Applicati
o
n > Research Materials
,
Applicati
o
n > Therapeutics
,
ResearchPr
o
ducts > Human Cell Lines
,
ResearchPr
o
ducts > Research Equipment
,
TherapeuticArea > End
o
crinology
,
TherapeuticArea > Immun
o
logy
,
TherapeuticArea > Metab
o
lic Disease
,
TherapeuticArea >
O
ncology
,
C
o
llaboration Sought > Collaboration
,
C
o
llaboration Sought > Licensing
EV-D68 M
o
noclonal Antibodies Isolated from Immunized Rhesus Macaques
Enter
o
virus D68 (EV-D68) has been linked to the widespread outbreaks of respiratory illness and acute flaccid myelitis (AFM) in the United States and Europe in 2014, 2016, and 2018. Although EV-D68 is now the most frequently encountered enterovirus (41.1% of cases), with an estimated global prevalence of 4%, there are no specific, FDA-approved therapeutic...
Published: 7/2/2025
|
Inventor(s):
Tracy Ruckwardt
,
Daniel M
o
ss
,
Peter Krug
,
Masaru Kanekiy
o
Keywords(s):
Category(s):
Applicati
o
n
,
Applicati
o
n > Diagnostics
,
Applicati
o
n > Therapeutics
,
Applicati
o
n > Vaccines
,
C
o
llaboration Sought
,
C
o
llaboration Sought > Licensing
,
C
o
llaboration Sought > Materials Available
,
ResearchPr
o
ducts
,
ResearchPr
o
ducts > Antibodies
,
TherapeuticArea
,
TherapeuticArea > Immun
o
logy
,
TherapeuticArea > Infecti
o
us Disease
Synergistic Interacti
o
ns for Improved Cancer Treatment
Summary: The Nati
o
nal Cancer Institute (NCI) seeks research co-development partners and/or licensees to develop hetIL-15 in combination with other agents, such as PPARa agonists (Fenofibrate), FLT3 inhibitors (quizartinib), IL-12, or chemotherapy into a therapeutic for cancer. Description of Technology: Immunotherapy has emerged as a promising treatment...
Published: 6/27/2025
|
Inventor(s):
Barbara Felber
,
Ge
o
rge Pavlakis
,
Sevasti Karali
o
ta
,
Dimitri
o
s Stellas
Keywords(s):
Category(s):
TherapeuticArea > Immun
o
logy
,
TherapeuticArea >
O
ncology
,
Applicati
o
n > Therapeutics
,
C
o
llaboration Sought > Collaboration
,
C
o
llaboration Sought > Licensing
Establishment and characterizati
o
n of the A 1847 human ovarian carcinoma line
Summary: The Nati
o
nal Cancer Institute (NCI) seeks licensees for a tumorigenic cell line, A1847, from a patient with metastatic ovarian cancer. As a BRCA1 deficient cell line, it serves as a model to researchers studying cell cycle regulation, tumor suppression and effective drugs aiding in repair of DNA damage. Description of Technology: Mutations,...
Published: 6/27/2025
|
Inventor(s):
Stuart Aar
o
nson
,
Nels
o
n Ellmore (Estate)
Keywords(s):
Category(s):
TherapeuticArea >
O
ncology
,
C
o
llaboration Sought > Licensing
,
Applicati
o
n > Research Materials
Zip14-AAV Genetic MRI Rep
o
rter System for Non-Invasive Cell & Gene-Therapy Tracking
This techn
o
logy includes a gene-based magnetic resonance imaging (MRI) reporter platform that harnesses adeno-associated virus (AAV) delivery of the metal transporter Zip14 to create image contrast wherever the gene is expressed. By driving Zip14 from cell-specific promoters, investigators obtain robust, long-lasting signal changes on standard clinical...
Published: 6/18/2025
|
Inventor(s):
Harikrishna (Hari) Rallapalli
,
Alan K
o
retsky
,
Raym
o
nd (Ray) Fields
Keywords(s):
Category(s):
Applicati
o
n > Diagnostics
,
Applicati
o
n > Therapeutics
,
TherapeuticArea > Neur
o
logy
,
TherapeuticArea > Radi
o
logy
,
C
o
llaboration Sought > Licensing
Angubindin-1 Peptide f
o
r Transient Blood-Brain Barrier Opening to Boost Chemotherapy in Malignant Glioma
This techn
o
logy includes a first-in-class synthetic peptide, angubindin-1, designed to temporarily relax the blood-brain barrier (BBB)—the tightly sealed network of brain blood vessel cells that normally blocks most drugs—from the inside. By binding the tricellular tight-junction protein angulin-1/LSR, the peptide creates a reversible “molecular...
Published: 6/13/2025
|
Inventor(s):
Sadhana Jacks
o
n
Keywords(s):
Category(s):
Applicati
o
n > Therapeutics
,
TherapeuticArea > Neur
o
logy
,
TherapeuticArea >
O
ncology
,
C
o
llaboration Sought > Licensing
O
ral Iron-Chelator Therapy for Treating Developmental Stuttering
This techn
o
logy discloses the use of small-molecule iron chelators—drugs that bind and remove excess iron—for the oral treatment of developmental stuttering in children and adults. Mouse models carrying human stuttering mutations show both elevated striatal iron and impaired vocalization; daily low-dose deferiprone reverses these speech-like...
Published: 6/13/2025
|
Inventor(s):
Shahriar SheikhBahaei
Keywords(s):
Category(s):
Applicati
o
n > Therapeutics
,
TherapeuticArea > Neur
o
logy
,
TherapeuticArea > Psychiatry/Mental Health
,
C
o
llaboration Sought > Licensing
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