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ID
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In-viv
o
System to Interrogate the Functions of Mucous Membranes and Identify Mucin/Glycan Mimetics and JAK/STAT Inhibitors for the Treatment of Diseases of the Oral Cavity and Digestive Tract
This techn
o
logy includes a Drosophila mutant strain that can be used as an in vivo model for diseases of the oral cavity and digestive tract (Sjogren's syndrome, colitis, colon cancer, inflammatory bowel disease), where the mucous membrane is disrupted or non-functional. This mutant lacks a mucous membrane and displays epithelial cell damage, uncontrolled...
Published: 12/26/2024
|
Inventor(s):
Liping Zhang
,
Kelly Ten Hagen
Keywords(s):
FUNCTI
O
NS
,
IDENTIFY
,
Inhibit
o
rs
,
Interr
o
gate
,
Jak/STAT
,
MEMBRANES
,
MIMETICS
,
Mucin/glycan
,
Muc
o
us
,
System
,
Viv
o
,
VPXXXX
,
WIXXXX
,
XEXXXX
Category(s):
TherapeuticArea >
O
ncology
,
TherapeuticArea > Infecti
o
us Disease
,
TherapeuticArea >
O
phthalmology
,
TherapeuticArea > End
o
crinology
,
TherapeuticArea > Dental
,
Applicati
o
n > Therapeutics
,
Applicati
o
n > Research Materials
,
TherapeuticArea > Cardi
o
logy
Flu
o
rinated MU-Opioid Receptor Agonists
Summary: Investigat
o
rs at the National Institute on Drug Abuse seek co-development partners and/or licensees for collection of mu opioid receptor (MOR) agonists as alternatives for existing compounds. Description of Technology: Although existing opioids are excellent analgesics and useful as positron emission tomography (PET) radiotracers, they come...
Published: 12/20/2024
|
Inventor(s):
Michael Michaelides
,
Juan G
o
mez
,
Kenner Rice
,
Agnieszka Sulima
,
Michael Baumann
Keywords(s):
Category(s):
Applicati
o
n
,
Applicati
o
n > Therapeutics
,
C
o
llaboration Sought > Collaboration
,
TherapeuticArea > Immun
o
logy
,
TherapeuticArea > Neur
o
logy
,
TherapeuticArea > Radi
o
logy
,
C
o
llaboration Sought > Licensing
Advanced Human Cell Line Techn
o
logy for RSV Replication Complex Production and Antiviral Drug Discovery
This techn
o
logy includes the NeurEx® mobile application, a groundbreaking tool designed for neurologists to conduct and document neurological examinations efficiently. Deployed on iPads, it integrates with a secure, cloud-based database, automating the computation of four key disability scales used in neuroimmunology. The app's robust design...
Published: 12/10/2024
|
Inventor(s):
Cyril Le N
o
uen
,
J
o
seph Marcotrigiano
,
Ursula Buchh
o
lz
,
Peter C
o
llins
Keywords(s):
Category(s):
Applicati
o
n > Research Materials
,
ResearchPr
o
ducts > Human Cell Lines
,
TherapeuticArea > Infecti
o
us Disease
Enhanced S10-3 Cell Line f
o
r Advanced Hepatitis E Virus Research and Therapeutic Development
The Huh-7 cell line underwent a detailed sub-cl
o
ning process to enhance its effectiveness for Hepatitis E Virus (HEV) infection studies. This involved diluting and culturing cells in 96-well plates until confluent monolayers formed, followed by selection and expansion of the most suitable cells. The sub-clone S10-3, derived from this process, was identified...
Published: 12/10/2024
|
Inventor(s):
Suzanne Emers
o
n
,
Hanh Nguyen
,
Udana T
o
rian
Keywords(s):
Category(s):
Applicati
o
n > Research Materials
,
ResearchPr
o
ducts
,
ResearchPr
o
ducts > Human Cell Lines
,
TherapeuticArea > Infecti
o
us Disease
A Fundamental T
o
ol for Efficient Recovery of RNA Viruses through Reverse Genetics
BSR T7/5 cells represent a f
o
undational advancement in virology, offering a robust platform for the recovery of RNA viruses via reverse genetics. Established over 20 years ago, these cells have proven instrumental in the recovery of a wide array of RNA viruses, particularly those belonging to the mononegavirales order. By enabling the insertion of antigenome...
Published: 12/10/2024
|
Inventor(s):
Ursula Buchh
o
lz
Keywords(s):
Category(s):
Applicati
o
n > Therapeutics
,
Applicati
o
n > Vaccines
,
C
o
llaboration Sought > Collaboration
,
C
o
llaboration Sought > Licensing
,
ResearchPr
o
ducts > Research Equipment
,
TherapeuticArea > Immun
o
logy
,
TherapeuticArea > Infecti
o
us Disease
A Key Advancement f
o
r Human Norovirus Research and Reverse Genetics
The HEK293T/T7 cell line is a n
o
vel development in virology research, particularly for studying human noroviruses. This cell line expresses the T7 RNA polymerase, a key enzyme used in reverse genetics systems. Unlike existing technologies, the HEK293T/T7 cell line offers the unique advantage of being able to produce functional T7 RNA polymerase, which...
Published: 12/10/2024
|
Inventor(s):
Carl
o
s Sandoval-Jaime
,
Stanislav S
o
snovtsev
Keywords(s):
Category(s):
Applicati
o
n > Therapeutics
,
Applicati
o
n > Vaccines
,
C
o
llaboration Sought > Collaboration
,
C
o
llaboration Sought > Licensing
,
ResearchPr
o
ducts > Human Cell Lines
,
TherapeuticArea > Infecti
o
us Disease
,
TherapeuticArea > Rare / Neglected Diseases
Bispecific Antib
o
dy Targeting Anthrax Toxins and Capsule for Enhanced Biodefense
The techn
o
logy focuses on the development of a tetravalent bispecific antibody effective against Bacillus anthracis, the bacterium responsible for anthrax. This antibody combines the specificities of two monoclonal antibodies (mAbs): one targeting anthrax protective antigen (PA) and the other targeting the bacterial capsule. The anti-PA mAb shows potent...
Published: 12/10/2024
|
Inventor(s):
Zha
o
Chun Chen
,
R
o
bert Purcell
,
Mahtab M
o
ayeri
,
Stephen Leppla
Keywords(s):
Category(s):
Applicati
o
n > Therapeutics
,
Applicati
o
n > Vaccines
,
C
o
llaboration Sought > Collaboration
,
C
o
llaboration Sought > Licensing
,
ResearchPr
o
ducts > Antibodies
,
TherapeuticArea > Immun
o
logy
,
TherapeuticArea > Infecti
o
us Disease
Advancements in P
o
stexposure Prophylaxis: Evaluating High-Potency Rabies-Neutralizing Monoclonal Antibodies
This techn
o
logy represents a significant advancement in the field of rabies prevention, focusing on the development of highly potent rabies-neutralizing monoclonal antibodies (mAbs) for use in postexposure prophylaxis (PEP). With two mAbs, F2 and G5a, displaying exceptional neutralizing titers of 1154 and 3462 International Units (IUs) per milligram,...
Published: 12/10/2024
|
Inventor(s):
Zha
o
chun Chen
,
R
o
bert Purcell
,
J
o
seph Blaney
Keywords(s):
Category(s):
Applicati
o
n > Diagnostics
,
Applicati
o
n > Therapeutics
,
Applicati
o
n > Vaccines
,
C
o
llaboration Sought > Collaboration
,
C
o
llaboration Sought > Licensing
,
ResearchPr
o
ducts > Antibodies
,
ResearchPr
o
ducts > Research Equipment
,
TherapeuticArea > Infecti
o
us Disease
Advancing VZV Antib
o
dy Detection: A High-Throughput LIPS Assay for Varicella Vaccine Recipients
The techn
o
logy described is a sophisticated and high-throughput luciferase immunoprecipitation system (LIPS) assay designed to detect antibodies specific to Varicella-zoster virus (VZV) glycoprotein E (gE). By transfecting cells with VZV protein-Renilla luciferase fusion protein constructs and subsequently performing immunoprecipitations with protein...
Published: 12/10/2024
|
Inventor(s):
Jeffrey C
o
hen
,
Peter Burbel
o
,
Mir Ali
Keywords(s):
Category(s):
Applicati
o
n > Diagnostics
,
C
o
llaboration Sought > Collaboration
,
C
o
llaboration Sought > Licensing
,
ResearchPr
o
ducts > Antibodies
,
ResearchPr
o
ducts > Research Equipment
,
TherapeuticArea > Infecti
o
us Disease
O
ptimizing RSV Infection Monitoring and High-Throughput Screening Through GFP Expression in the First-Gene Position of Respiratory Syncytial Virus (RSV) Strain A2
In this techn
o
logy, researchers have engineered a modified version of Respiratory Syncytial Virus (RSV) strain A2 using reverse genetics to incorporate green fluorescent protein (GFP) into the first-gene position. This genetic modification allows for the efficient monitoring of RSV infection and the screening of potential chemical inhibitors. The GFP...
Published: 12/10/2024
|
Inventor(s):
Peter C
o
llins
,
Ursula Buchh
o
lz
,
Cindy Lu
o
ngo
Keywords(s):
Category(s):
Applicati
o
n > Diagnostics
,
Applicati
o
n > Research Materials
,
Applicati
o
n > Therapeutics
,
C
o
llaboration Sought > Collaboration
,
C
o
llaboration Sought > Licensing
,
ResearchPr
o
ducts > Computational models/software
,
ResearchPr
o
ducts > Research Equipment
,
TherapeuticArea > Infecti
o
us Disease
,
TherapeuticArea > Respirat
o
ry
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