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O
xynitidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) for Treating Cancer
Summary: The Nati
o
nal Cancer Institute (NCI) is actively seeking potential licensees and/or co-development research collaboration partners interested in advancing oxynitidine derivatives as novel inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) for cancer treatment. These TOPI and TDP1 inhibitors, when administered...
Published: 9/18/2024
|
Inventor(s):
Yves P
o
mmier
,
Lin-kun An
,
Keli Agama
,
Evgeny Kiselev
,
Azhar Ravji
Keywords(s):
Benz
o
phenanthridine Derivatives
,
Benz
o
phenanthridinone
,
Campt
o
thecin
,
Dihydr
o
benzophenanthridine
,
IRIN
O
TECAN
,
O
xynitidine
,
P
o
mmier
,
Tdp1
,
T
O
P1
,
T
o
poisomerase 1B
,
T
o
potecan
,
Tyr
o
syl-DNA Phosphodiesterase 1
Category(s):
C
o
llaboration Sought > Licensing
,
C
o
llaboration Sought > Collaboration
,
TherapeuticArea >
O
ncology
,
Applicati
o
n > Therapeutics
Single S
o
urce-Detector Separation Approach to Calculate Tissue Oxygen Saturation
Summary: The Nati
o
nal Institute of Child Health and Human Development (NICHD) seeks partners and/or licensees to further develop and commercialize the miniaturized tissue oximeter for implementing the single source-detector separation algorithm in existing devices/systems to collect tissue oxygen saturation. Description of Technology: Tissue oxygen...
Published: 9/18/2024
|
Inventor(s):
Thien Nguyen
,
Amir Gandjbakhche
,
S
o
ongho Park
,
Brian Hill
Keywords(s):
Category(s):
Applicati
o
n > Medical Devices
,
C
o
llaboration Sought > Collaboration
,
TherapeuticArea > Respirat
o
ry
,
TherapeuticArea > Neur
o
logy
,
TherapeuticArea > Infecti
o
us Disease
Meth
o
ds of Detecting Loss of Heterozygosity and Damaging Mutations in Immune-Related Genes Using Liquid Biopsies
Summary: The Nati
o
nal Cancer Institute (NCI) seeks co-development partners and/or licensees for a liquid biopsy diagnostic assay capable of detecting loss of heterozygosity (LOH) and somatic mutations in genes important for antigen processing and presentation and interferon-γ response pathways. Description of Technology: Immunotherapy is...
Published: 9/13/2024
|
Inventor(s):
Sc
o
tt Norberg
,
Andrew Sink
o
e
,
Xia
o
lin Wu
,
James Gulley
Keywords(s):
Category(s):
Applicati
o
n > Diagnostics
,
C
o
llaboration Sought > Collaboration
,
TherapeuticArea >
O
ncology
,
TherapeuticArea > Immun
o
logy
Impr
o
ved Methods For Cryopreservation Of Cells, Tissues, And Organs
Summary: The Nati
o
nal Eye Institute seeks research co-development partners and/or licensees for novel methods of cryopreserving cells, tissues, and organs via FOXO1 activation and other mechanisms. Description of Technology: The cornea is a critical part of the eye that helps prevent debris from entering and refracts light for proper vision. Corneal...
Published: 9/9/2024
|
Inventor(s):
Jingxing
O
u
,
Kiy
o
haru Miyagishima
,
Guanghui Jin
,
Wei Li
,
Liha
o
Ge
Keywords(s):
Category(s):
Applicati
o
n
,
Applicati
o
n > Research Materials
,
C
o
llaboration Sought > Collaboration
,
TherapeuticArea > Eye / Ear / N
o
se / Throat
Using Artificial Intelligence T
o
Diagnose Uveitis
Summary: The Nati
o
nal Eye Institute seeks research co-development partners and/or licensees for a deep learning algorithm that can identify retinal vasculitis using color fundus images. Description of Technology: Uveitis is caused by inflammation in the eye that can cause pain and reduce vision. The rate of uveitis in the United States is 1 in every...
Published: 8/14/2024
|
Inventor(s):
Shilpa K
o
dati
,
J
o
ngwoo Kim
,
Nam Nguyen
Keywords(s):
Category(s):
Applicati
o
n > Diagnostics
,
C
o
llaboration Sought > Collaboration
,
TherapeuticArea > Eye / Ear / N
o
se / Throat
Using Artificial Intelligence T
o
Predict The Risk Of Age-Related Macular Degeneration
Summary: The Nati
o
nal Eye Institute seeks research co-development partners and/or licensees for a deep learning algorithm that can predict the probability of progression to late age-related macular degeneration. Description of Technology: In 2024, an estimated 200 million people worldwide suffer from age-related macular degeneration (AMD); projected...
Published: 8/14/2024
|
Inventor(s):
Emily Chew
,
Zhiy
o
ng Lu
,
Tiarnan Keenan
,
Wai W
o
ng
,
Qingyu Chen
,
Elvira Agr
o
n
Keywords(s):
Category(s):
Applicati
o
n > Diagnostics
,
C
o
llaboration Sought > Collaboration
,
TherapeuticArea > Eye / Ear / N
o
se / Throat
TYR
O
SINASE Gene Therapy for Oculocutaneous Albinism type 1A
Summary: The Nati
o
nal Eye Institute seeks research co-development partners and/or licensees for an adeno-associated viral gene therapy for Oculocutaneous Albinism type 1A. Description of Technology: Oculocutaneous albinism (OCA) is a genetically heterogeneous congenital disorder characterized by decreased or absent pigmentation in the hair,...
Published: 8/14/2024
|
Inventor(s):
Brian Br
o
oks
,
Aman Ge
o
rge
Keywords(s):
Category(s):
Applicati
o
n
,
Applicati
o
n > Therapeutics
,
C
o
llaboration Sought > Collaboration
,
TherapeuticArea > Eye / Ear / N
o
se / Throat
,
TherapeuticArea > Rare / Neglected Diseases
,
TherapeuticArea >
O
phthalmology
Interleukin-27 Pr
o
ducing B-Cell Population and Uses Thereof
Summary: The Nati
o
nal Eye Institute (NEI) seeks research co-development partners and/or licensees to advance the production and uses of interleukin-27 (IL-27) producing B-regulatory cell (i27-Breg) therapy for immune related autoimmune disorders. These disorders include but are not limited, to age-related macular degeneration (AMD), graft-versus-host...
Published: 8/14/2024
|
Inventor(s):
Charles Egwuagu
,
Jin Ch
o
i
Keywords(s):
Category(s):
Applicati
o
n > Therapeutics
,
C
o
llaboration Sought > Collaboration
,
TherapeuticArea > Eye / Ear / N
o
se / Throat
,
TherapeuticArea > Neur
o
logy
,
TherapeuticArea > Immun
o
logy
Using FDA-appr
o
ved Small Molecule Drug Reserpine and related compounds (especially Halofantrine) To Protect Photoreceptors In Inherited Retinal Degenerations And Age-Related Macular Degeneration
Summary: The Nati
o
nal Eye Institute seeks research co-development partners and/or licensees for a therapy using an FDA-approved small molecule drug reserpine (and related compounds especially halofantrine) that prevents photoreceptor cell death in retinal degenerations. Description of Technology: Inherited Retinal Degenerations (IRD), such as Leber...
Published: 9/18/2024
|
Inventor(s):
Anand Swar
o
op
,
Yu H
o
lly Chen
,
Samantha Papal
,
Anupam M
o
ndal
,
Manju Swar
o
op
,
Wei Zheng
,
Greg
o
ry Tawa
,
Wenwei Huang
,
Zhiji Lu
o
Keywords(s):
Category(s):
Applicati
o
n > Therapeutics
,
C
o
llaboration Sought > Collaboration
,
TherapeuticArea > Eye / Ear / N
o
se / Throat
Meth
o
ds of Detecting Loss of Heterozygosity and Damaging Mutations in Immune-Related Genes Using Liquid Biopsies
Summary: The Nati
o
nal Cancer Institute (NCI) seeks co-development partners and/or licensees for a liquid biopsy diagnostic assay capable of detecting loss of heterozygosity (LOH) and somatic mutations in genes important for antigen processing and presentation and interferon-γ response pathways. Description of Technology: Immunotherapy is...
Published: 7/26/2024
|
Inventor(s):
Sc
o
tt Norberg
,
Andrew Sink
o
e
,
Xia
o
lin Wu
,
James Gulley
Keywords(s):
Category(s):
Applicati
o
n > Diagnostics
,
C
o
llaboration Sought > Collaboration
,
TherapeuticArea >
O
ncology
,
TherapeuticArea > Immun
o
logy
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