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M
o
noclonal Antibody for Specific Detection of the Transcription Factor Eos (Ikzf4) in Regulatory T Cells
Regulat
o
ry T cells (Tregs) are immune cells that keep the immune system balanced and prevent autoimmunity. Tregs depend on a protein called Eos (Ikzf4) that helps turn genes on and off for their development and function, but until now, antibodies used to detect and study Eos were unreliable. Researchers at the National Institute of Allergy and Infectious...
Published: 6/3/2026
|
Updated: 6/3/2026
|
Inventor(s):
Ethan Shevach
,
Angela DeVic
o
,
Patricia K
o
rty
Keywords(s):
Category(s):
ResearchPr
o
ducts
,
Applicati
o
n
,
Applicati
o
n > Diagnostics
,
Applicati
o
n > Therapeutics
MmabΔ3-7/Δ3-7 m
o
use model of metabolism of cobalamin associated B (MMAB) for the study of methylmalonic acidemia (MMA)
Is
o
lated Methylmalonic Acidemia (MMA) comprises a relatively common and heterogeneous group of inborn errors of metabolism. One cause of isolated MMA is genetic deficiency of the enzyme ATP:cob(I)alamin adenosyltransferase encoded by the metabolism of cobalamin associated B (MMAB) gene. MMAB deficiency, also called the cobalamin B type (cblB) of MMA...
Published: 5/28/2026
|
Updated: 5/28/2026
|
Inventor(s):
Charles Venditti
,
Eun-Y
o
ung Choi
Keywords(s):
Category(s):
Applicati
o
n > Research Materials
,
TherapeuticArea > Rare/Neglected Diseases
,
ResearchPr
o
ducts
,
ResearchPr
o
ducts > Animal Models
,
C
o
llaboration Sought
,
C
o
llaboration Sought > Licensing
,
C
o
llaboration Sought > Collaboration
,
C
o
llaboration Sought > Materials Available
Human-B
o
vine Reassortant Rotavirus Vaccine
R
o
tavirus is a major cause of severe diarrhea and dehydration in infants and young children. Vaccines that cover the most important rotavirus serotypes could help reduce serious illness worldwide. Researchers at NIAID’s Laboratory of Infectious Diseases developed a multivalent human-bovine reassortant rotavirus vaccine using vaccine strains created...
Published: 5/28/2026
|
Updated: 5/28/2026
|
Inventor(s):
Albert Kapikian (Estate
O
f)
,
R
o
bert Chanock (Estate)
,
Yasutaka H
o
shino
Keywords(s):
Category(s):
TherapeuticArea
,
Applicati
o
n > Vaccines
Human antib
o
dies with anti-lymphocyte specificities and lytic activity
Antib
o
dy therapies that target human B cells are a promising way to treat diseases like B-cell cancers and autoimmune conditions like lupus and multiple sclerosis. Traditionally, these antibodies are made in animals and modified to resemble human antibodies to reduce immune rejection. Researchers in the Laboratory of Immunoregulation (LIR) at the National...
Published: 5/21/2026
|
Updated: 5/21/2026
|
Inventor(s):
Ainh
o
a Perez-Diez
,
Irini Sereti
Keywords(s):
Category(s):
Applicati
o
n
,
ResearchPr
o
ducts > Antibodies
,
TherapeuticArea
A N
o
vel Strategy to Produce 6-cys Proteins Based on Pfs230D1 Domain Fusions
The Plasm
o
dium parasite has a complex lifecycle during human infection and in the mosquito vector. Most advanced malaria vaccine candidates can confer only partial, short-term protection in malaria-endemic areas. A means of breaking the transmission of malaria to subsequent individuals could prevent a significant amount of human disease. The primary...
Published: 5/14/2026
|
Updated: 5/14/2026
|
Inventor(s):
Patrick Duffy
,
J
o
nathan Renn
Keywords(s):
Category(s):
Applicati
o
n
,
Applicati
o
n > Research Materials
,
Applicati
o
n > Therapeutics
,
Applicati
o
n > Vaccines
,
C
o
llaboration Sought
,
C
o
llaboration Sought > Collaboration
,
C
o
llaboration Sought > Licensing
,
C
o
llaboration Sought > Materials Available
,
ResearchPr
o
ducts > Sequences
,
TherapeuticArea > Immun
o
logy
,
TherapeuticArea > Infecti
o
us Disease
Drug-Regulatable, Inducible Expressi
o
n of Membrane-Bound Interleukin 12 (DRIM-IL-12) for Use in Adoptive Cell Therapy
Summary: Scientists at the Nati
o
nal Cancer Institute (NCI) have developed a novel tightly regulated drug-responsive, membrane-bound IL-12 cytokine platform, that enhances anti-tumor efficacy in adoptive cell therapy (ACT) with engineered T-cells (CAR, TCR, TILs) while improving safety. The NCI seeks research co-development partners and/or licensees...
Published: 5/14/2026
|
Updated: 5/14/2026
|
Inventor(s):
Steven R
o
senberg
,
Sanghyun (Peter) Kim
Keywords(s):
Category(s):
Applicati
o
n > Therapeutics
,
TherapeuticArea > Immun
o
logy
,
TherapeuticArea >
O
ncology
,
C
o
llaboration Sought > Licensing
,
C
o
llaboration Sought > Collaboration
Angubindin-1 Peptide f
o
r Transient Blood-Brain Barrier Opening to Boost Chemotherapy in Malignant Glioma
This techn
o
logy includes a first-in-class synthetic peptide, angubindin-1, designed to temporarily relax the blood-brain barrier (BBB)—the tightly sealed network of brain blood vessel cells that normally blocks most drugs—from the inside. By binding the tricellular tight-junction protein angulin-1/LSR, the peptide creates a reversible “molecular...
Published: 4/30/2026
|
Updated: 4/30/2026
|
Inventor(s):
Sadhana Jacks
o
n
Keywords(s):
Category(s):
Applicati
o
n > Therapeutics
,
TherapeuticArea > Neur
o
logy
,
TherapeuticArea >
O
ncology
,
C
o
llaboration Sought > Licensing
Neutralizing M
o
noclonal Antibodies Against West Nile Virus
West Nile virus (WNV) is a m
o
squito-borne flavivirus that can cause fever and, in some cases, severe neurologic disease. There is no approved human vaccine or specific antiviral treatment for WNV. Researchers at NIAID's Vaccine Research Center (VRC), working with collaborators at Sheba Medical Center under the PREMISE program, identified...
Published: 4/24/2026
|
Updated: 4/24/2026
|
Inventor(s):
Daniel D
o
uek
,
Chaim Schramm
,
Ananda Ch
o
wdhury
,
Parker Dabbs
,
Lu Wang
,
Le
o
nid Serebryannyy
,
The
o
dore Pierson
,
Kimberly D
o
wd
,
Laura Vanblargan
,
Katherine Burg
o
master
,
David G
o
rdon
,
Yuxiang Wang
,
Yaniv Lustig
,
Yael
O
ttolenghi
,
Dr
o
r Harats
,
Sarah Smith (Kerscher)
Keywords(s):
Category(s):
Applicati
o
n
,
ResearchPr
o
ducts > Virus/Bacteria
,
ResearchPr
o
ducts
,
ResearchPr
o
ducts > Antibodies
,
TherapeuticArea
,
Applicati
o
n > Diagnostics
Neutralizing Antib
o
dies Against West Nile Virus
West Nile virus (WNV) is a m
o
squito-borne virus that can cause severe disease affecting the brain and nervous system, especially in older adults and people with weakened immune systems. There is no approved human vaccine or specific antiviral treatment for WNV. Researchers at NIAID’s Vaccine Research Center (VRC), together with collaborators...
Published: 4/23/2026
|
Updated: 4/22/2026
|
Inventor(s):
The
o
dore Pierson
,
Kimberly D
o
wd
,
Daniel D
o
uek
,
Dr
o
r Harats
,
Yael
O
ttolenghi
,
Gili Regev-Y
o
chay
,
Yaniv Lustig
Keywords(s):
Category(s):
TherapeuticArea
,
Applicati
o
n > Vaccines
,
Applicati
o
n
,
Applicati
o
n > Diagnostics
,
ResearchPr
o
ducts
,
ResearchPr
o
ducts > Virus/Bacteria
Meth
o
ds To Regulate Metabolism For Treatment Of Neural Injuries and Neurodegeneration
Descripti
o
n of Technology: Axonal injury and subsequent neuronal death underpin the pathology of many neurological disorders from acute neural injuries (motor vehicle crashes, combat related injuries, traumatic brain injuries) to neurological diseases (multiple sclerosis, glaucoma). In the central nervous system (CNS), microglia help respond to CNS...
Published: 4/16/2026
|
Updated: 4/16/2026
|
Inventor(s):
Wei Li
,
Jingxing
O
u
,
Tantai Zha
o
Keywords(s):
Category(s):
Applicati
o
n > Therapeutics
,
C
o
llaboration Sought > Collaboration
,
TherapeuticArea > Ear, N
o
se, & Throat
,
TherapeuticArea > Neur
o
logy
,
C
o
llaboration Sought > Licensing
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