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Bivalent Tn5 Complex and its Application to Map Enhancer-Promoter Interactions for Use in Diagnostics

This technology includes a new reagent, termed bivalent Tn5 complex, and applied it to mapping genome-wide enhancer-promoter interactions to be utilized for disease diagnostics. Chromatin structure is critical for regulating transcription in normal development and disease states. In particular, the interaction between enhancers and promotes are essential...

Published: 8/12/2024 | Inventor(s): Keji Zhao, Qingsong Tang

Keywords(s):

Category(s): Application > Diagnostics, Collaboration Sought > Licensing, ResearchProducts > Research Equipment

PET Imaging of lntegrin Expression with Suitably Labeled RGD Peptides for Multiple Diagnostic Purposes

This technology includes a number of dimeric RGD peptides which been developed and labeled with various PET isotopes (1BF, 68Ga, and 64Cu) for imaging integrin expression in cancer, inflammation, rheumatoid arthritis, myocardial infarct, stroke and traumatic injury. A number of these peptides have been translated into clinic for diagnosis and therapy...

Published: 8/12/2024 | Inventor(s): Xiaoyuan (Shawn) Chen, Lixin Lang, Gang NIU

Keywords(s):

Category(s): Application > Diagnostics, Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, TherapeuticArea > Immunology, TherapeuticArea > Neurology

An Automated System for Myocardial Perfusion Mapping and Machine Diagnosis to Detect Ischemic Heart Disease with First-pass Perfusion Cardiac Magnetic Resonance Imaging

This technology includes a fully automated computer aided diagnosis system to quantify myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) pixel maps from the first-pass contrast-enhanced cardiac magnetic resonance (CMR) perfusion images. This system performs automated image registration, motion compensation, segmentation, and modeling...

Published: 8/12/2024 | Inventor(s): Li-Yueh Hsu, Andrew Arai, Matthew Jacobs, Mitchel Benovoy

Keywords(s):

Category(s): Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology

Electronic Fringe Scanning for the Improvement of Medical Imaging Technology

This technology includes an electronic method for fringe scanning in grating-based phase-contrast imaging, which enhances x-ray phase-contrast imaging. Traditional methods use high-density gratings and require fine grating fringes, finer than the detector's resolution, necessitating fringe scanning to obtain phase-contrast information. This process...

Published: 8/12/2024 | Inventor(s): Han Wen

Keywords(s):

Category(s): Application > Medical Devices, Collaboration Sought > Licensing, ResearchProducts > Research Equipment

Encapsulation of Fluorescent Nanodiamonds into Poly-dopamine (PDA) Shell and Further Covalent Functionalization of the PDA Shell for Diagnostic Imaging Applications

This technology includes a new class of nanoparticles in the carbon family, fluorescent nanodiamonds (FNDs), exhibiting superb physical and chemical properties for diagnostic imaging applications. We have developed a simple, fast, and robust method to encapsulate FNDs in polydopamine that can be further functionalized. By integrating anatomical and...

Published: 4/8/2024 | Inventor(s): Haksung Jung, Keir Neuman

Keywords(s):

Category(s): Application > Medical Devices, Collaboration Sought > Licensing, ResearchProducts > Research Equipment

Background-free Imaging by Selective Modulation of Nanodiamond Fluorescence Using a Magnetic Field

This technology includes the use of nanodiamonds to achieve background-free imaging. We present several techniques to reduce or eliminate background florescence by exploiting properties of the fluorescent nanodiamonds. In particular, magnetic field modulation of the fluorescence intensity offers a simple, robust, and easily adaptable method to obtain...

Published: 8/12/2024 | Inventor(s): Ambika Bumb, Susanta Sarkar, Keir Neuman

Keywords(s):

Category(s): Application > Diagnostics, Application > Medical Devices, Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment

3D Bioprinting of Cardiac Patch with Anisotropic and Perfusable Architecture for the Repair of Damaged Cardiac Muscle

This technology includes a novel cardiac patch which was 3D printed to repair damaged cardiac tissue. Based on biological and anatomical understanding of myocardial tissue, a novel 3D bioprinting technique was developed to directly fabricate the cellularized and vascularized cardiac patch with anisotropic fiber and perfusable vessel architecture. The...

Published: 8/12/2024 | Inventor(s): Lijie Zhang, Haitao Cui, Yimin Huang

Keywords(s):

Category(s): Application > Medical Devices, Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology

Systems and Methods for Retrieving Implanted Magnets

This technology includes a strategy for retrieving a pair of implanted magnets from a patient’s body. This method includes maneuvering a guide catheter with a guide magnet on the distal end. Current methods are geared toward magnetic compression occurring in the digestive system, while this method can be used as a less invasive method for cardiac...

Published: 8/15/2024 | Inventor(s): Shaun Gittard, Kanishka Ratnayaka

Keywords(s):

Category(s): Application > Medical Devices, Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology

Development of High-Throughput ELISA Based Binding Assays to Detect p53/p63/p73 Family Protein-DNA Interaction in the 96-well Microplate Format for Drug Screening and Other Clinical and Diagnostic Uses

This technology includes ELISA based binding assays of p53, p63 or p73 provide possibilities to validate genome sequencing results, and allow the performance of more in-depth investigation to address scientific mechanisms, as well as to develop applications for high-throughput clinical and diagnosis usages. While quantitative p53 binding assays have...

Published: 8/12/2024 | Inventor(s): Zhong Chen, Minyoung Jang

Keywords(s):

Category(s): Application > Diagnostics, Application > Research Materials, ResearchProducts > Research Equipment, TherapeuticArea > Oncology

Genetic Manipulation of Natural Killer Cells to Express c-MPL Growth Factor Receptor as a Therapy for Cancer

This technology includes genetic manipulation of natural killer (NK) cells to express thrombopoietin receptor (c-MPL) growth factor receptor as strategy to augment NK cell proliferation and anti-tumor immunity. Many investigational adoptive immunotherapy regimens utilizing NK cells require the administration of IL-2 or IL-15 cytokines to support the...

Published: 8/12/2024 | Inventor(s): David Allan, Richard Childs

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Oncology

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