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Enhanced Tissue Clearing Solution, Clearing-Enhanced 3D (Ce3D), Compatible with Advanced Fluorescence Microscopy Imaging
Case ID:
TAB-3241
Web Published:
12/6/2022
Description:
NIH immunologists have created a solution, Clearing-enhanced 3D (Ce3D), that can be used to make entire organs extremely transparent (top right panel). This allows the tissue to be imaged using advanced fluorescence microscopy techniques (bottom panel). Unlike current tissue clearing solutions, the Ce3D tissue clearing solution is robustly compatible with a variety of staining methods, and preserves tissue morphology and reporter fluorescence. Ce3D enabled microscopy provides unprecedented insight into the spatial organization of cells within intact organs. Further, when Ce3D enabled microscopy is coupled with multiplexed staining and a newly developed analysis pipeline, investigators are able to extensively characterize densely packed cells in situ, providing advantages to phenotyping cells with flow cytometric techniques.
This technology is available for licensing for commercial development in accordance with 35 U.S.C. 209 and 37 CFR part 404, as well as for further development and evaluation under a research collaboration.
Patent Information:
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Direct Link:
https://nih.technologypublisher.com/tech?title=Enhanced_Tissue_Clearing_Solut ion%2c_Clearing-Enhanced_3D_(Ce3D)%2c_Compatible_with_Advanced_Fluorescence_ Microscopy_Imaging
Category(s):
Collaboration
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For Information, Contact:
Daniel Lee
TTPS/Technology Transfer Manager
NIH Technology Transfer
301-761-6327
daniel.lee5@nih.gov
Inventors:
Michael Gerner
Weizhe Li
Ronald Germain
Keywords:
3D
AA3AXX
Ce3D:
Cellular
Clearing
Epitope
Fluorescence
histo-cytometry
IMAGING
imaging agent
Method
MICROSCOPY
REPORTER
Tissue
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